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MRI-based research advances in the glymphatic system in Alzheimer's disease
HU Yuxin  SU Yunyan  YAO Hui  YANG Yiwen  YAN Suoyu 

Cite this article as: HU Y X, SU Y Y, YAO Hui, et al. MRI-based research advances in the glymphatic system in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2025, 16(7): 109-116. DOI:10.12015/issn.1674-8034.2025.07.018.


[Abstract] With the acceleration of global aging, research on the pathogenesis of Alzheimer's disease (AD) has become a central issue in neuroscience. The glymphatic system (GS), a perivascular network responsible for the clearance of metabolic waste in the central nervous system, plays a key role in the accumulation of amyloid-beta (Aβ) and Tau pathology associated with AD. Early visualization of structural and functional changes in GS is important to diagnose some of the neurodegenerative diseases and develop new therapeutic options. In recent years, multimodal magnetic resonance imaging (MRI) techniques—including dynamic contrast-enhanced MRI (DCE-MRI), diffusion tensor imaging analysis along the perivascular space (DTI-ALPS), chemical-exchange-saturation-transfer MRI (CEST-MRI), and resting state functional MRI (rs-fMRI)—have gradually visualized the structure and function of GS in a noninvasive or minimally invasive way. In this paper, we review the preclinical and clinical research evidence and dynamically monitor the GS functional changes and influx-efflux pathways using multimodal MRI technology. By elucidating visualized evidence of GS dysfunction and identifying associated neuroimaging biomarkers, this work aims to provide novel insights into early AD diagnosis and the underlying pathological mechanisms.
[Keywords] Alzheimer's disease；glymphatic system；magnetic resonance imaging；diffusion tensor imaging analysis along the perivascular space

HU Yuxin1   SU Yunyan1*   YAO Hui2   YANG Yiwen1   YAN Suoyu1  

1 Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

2 Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

Corresponding author: SU Y Y, E-mail: suyunyanhappy@163.com

Conflicts of interest   None.

Received  2025-04-21
Accepted  2025-07-07
DOI: 10.12015/issn.1674-8034.2025.07.018
Cite this article as: HU Y X, SU Y Y, YAO Hui, et al. MRI-based research advances in the glymphatic system in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2025, 16(7): 109-116. DOI:10.12015/issn.1674-8034.2025.07.018.

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