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Research progress of multimodal MRI technology on the changes in brain function of patients with amblyopia
JIA Jinjin  JIA Jing  SUN Yan  YAN Xingke 

Cite this article as: JIA J J, JIA J, SUN Y, et al. Research progress of multimodal MRI technology on the changes in brain function of patients with amblyopia[J]. Chin J Magn Reson Imaging, 2025, 16(7): 117-123. DOI:10.12015/issn.1674-8034.2025.07.019.


[Abstract] The impairment of visual function in patients with amblyopia is closely related to the changes in brain function. MRI technology enables precise imaging of the brain's structure and function under non-invasive conditions, allowing for an in-depth analysis of the characteristics and mechanisms of the changes in brain function in amblyopia. This article summarizes the literature on the use of MRI technology in recent years to study the brain function mechanisms in patients with amblyopia. Structural MRI shows that the gray matter volume and cortical thickness in brain regions related to the visual pathway of amblyopic patients is reduced. Functional MRI, through task-based fMRI, reveals reduced activation of the visual cortex, and resting-state fMRI shows abnormalities in the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) values of neurons in local brain regions, changes in the functional connectivity of the primary and secondary visual pathways, as well as alterations in brain functional networks such as the default mode network and the salience network. Diffusion MRI reveals a decrease in the fractional anisotropy (FA) value and an increase in the mean diffusivity (MD) value of white matter fiber tracts. Magnetic resonance spectroscopy (MRS) shows a decrease in the γ-aminobutyric acid (GABA) level in the visual cortex. Based on the arterial spin labeling (ASL) cerebral perfusion imaging technique, it has been found that cerebral blood perfusion in certain brain regions of amblyopic patients is reduced. This article reviews the contents mentioned above, aiming to provide more references for the study of the brain mechanisms of amblyopia.
[Keywords] amblyopia；brain function；magnetic resonance imaging；structural magnetic resonance imaging；functional magnetic resonance imaging

JIA Jinjin1   JIA Jing2   SUN Yan3   YAN Xingke2*  

1 Department of Traditional Chinese Medicine, Qinghai Unversity Medical College, Xining 810016, China

2 School of Acupuncture and Massage, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

3 Lanzhou Bright Eye Hospital, Lanzhou 730000, China

Corresponding author: YAN X K, E-mail: yanxingke@126.com

Conflicts of interest   None.

Received  2025-04-12
Accepted  2025-07-07
DOI: 10.12015/issn.1674-8034.2025.07.019
Cite this article as: JIA J J, JIA J, SUN Y, et al. Research progress of multimodal MRI technology on the changes in brain function of patients with amblyopia[J]. Chin J Magn Reson Imaging, 2025, 16(7): 117-123. DOI:10.12015/issn.1674-8034.2025.07.019.

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