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• Clinical Article •
A preliminary study based on diffusion tensor imaging in brain microstructure of substantia nigra and insular leaf of Parkinson's disease patients with frozen gait
ZANG Renli  WANG Hong  PAN Wei  YE Lili  FENG Yi  WEI Yuxin  ZHENG Xiaolin 

DOI:10.12015/issn.1674-8034.2025.08.003.


[Abstract] Objective Diffusion tensor imaging (DTI) technique was used to investigate the changes of brain microstructure of substantia nigra and insula in patients with frozen gait of Parkinson's disease patients with frozen gait (PD-FOG).Materials and Methods Thirty-five cases of PD-FOG patients were included as the case group, and twenty-four healthy control (HC) were included as the control group. All patients underwent scans of DTI, and fractional anisotropy (FA) images were obtained. The FA values in the substantia nigra and insula regions were measured separately, and the differences between the case group and the control group were compared.Results The bilateral substantia nigra and insula FA values of the PD-FOG group were significantly different from those of the HC group (P < 0.05). The area under the curve (AUC) of the receiver operating characteristic (ROC) curve of the left insula FA value in the PD-FOG group was the largest, followed by the right substantia nigra FA value, the left substantia nigra A value, the right insula A value, with AUC values of 0.849, 0.812, 0.789, and 0.657, respectively. The correlation analysis between the FA values of the substantia nigra and insula and the Unified Parkinson's Disease Rating Scale (UPDRS) score showed that the right substantia nigra FA value (r = -0.693, P = 0.005), the left substantia nigra FA value (r = -0.638, P = 0.014), and the left insula FA value (r = -0.516, P = 0.014) were negatively correlated with the UPDRS score, while the right insula FA value was not significantly correlated with the UPDRS score.Conclusions DTI not only reflects the brain microstructural variation between the insula regions and substantia nigra of patients with PD and freezing gait, but also it can reveal the correlation between FA values and the UPDRS score scale, providing clinical assistance for the prevention and intervention of freezing gait in PD patients.
[Keywords] Parkinson's disease；frozen gait；magnetic resonance imaging；diffusion tensor imaging；substantia nigra；insular leaf；fractional anisotropy

ZANG Renli   WANG Hong*   PAN Wei   YE Lili   FENG Yi   WEI Yuxin   ZHENG Xiaolin  

Department of Radiology, Kanghua Hospital of Dongguan, Dongguan 523000, China

Corresponding author: WANG H, E-mail: 544202170@qq.com

Conflicts of interest   None.

Received  2024-12-19
Accepted  2025-07-04
DOI: 10.12015/issn.1674-8034.2025.08.003
DOI:10.12015/issn.1674-8034.2025.08.003.

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