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• Clinical Article •
Study on the value of MRI multiple b-value DWI quantitative parameters in predicting lymphovascular invasion of gastric cancer
YU Wenwei  LI Qiong  WEI Xiaoxue  SANG Zitong  HOU Yajun  LIU Xisheng 

DOI:10.12015/issn.1674-8034.2025.08.013.


[Abstract] Objective To investigate the efficacy of MRI multiple b-value diffusion weighted imaging (DWI) quantitative parameters in predicting lymphovascular invasion of gastric cancer.Materials and Methods Two hundred and thirty gastric cancer patients who underwent radical gastrectomy and gastric MRI examination before the operation. The patients were divided into positive group and negative group according to postoperative pathological results for lymphorascular invasion. The preoperative image T-staging and image N-staging were evaluated, and the lesion thickness, lesion volume and quantitative parameters of mono-exponential mode (MEM), intravoxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI) and stretched exponential model (SEM) of the patients were measured. Logistic regression analysis was used to screen out independent risk factors with positive lymphovascular invasion, receiver operating characteristic (ROC) curve was used to evaluate the efficacy of each parameter in identifying lymphovascular invasion status, and DeLong test was used to compare the efficacy of each parameter.Results There were statistical differences in image T-staging, image N-staging, lesion thickness, lesion volume, apparent diffusion coefficient (ADC) of MEM, mean kurtosis (MK) of DKI, diffusion coefficient (D) and pseudodiffusion coefficient (D*) of IVIM and α of SEM between two groups (all P < 0.05). The area under the curve (AUC) values of DKI_MK, image N-staging and combined models were 0.809 [95% confidence interval (CI): 0.752 to 0.866], 0.666 (0.596 to 0.736) and 0.828 (0.776 to 0.879), respectively. There was no significant difference between DKI_MK and combined model (P > 0.05).Conclusions MRI multiple b-value DWI quantitative parameters can predict lymphovascular invasion in gastric cancer effectively before operation.
[Keywords] gastric cancer；magnetic resonance imaging；diffusion weighted imaging；lymphovascular invasion；preoperative evaluation；prediction

YU Wenwei   LI Qiong   WEI Xiaoxue   SANG Zitong   HOU Yajun   LIU Xisheng*  

Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Corresponding author: LIU X S, E-mail: njmu_lxs@163.com

Conflicts of interest   None.

Received  2025-03-22
Accepted  2025-07-07
DOI: 10.12015/issn.1674-8034.2025.08.013
DOI:10.12015/issn.1674-8034.2025.08.013.

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