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Research advances in magnetic resonance imaging for cognitive impairment in prediabetes mellitus
XIANG Yu  YANG Siyi  TIAN Bin  HE Qing  LI Shiguang 

DOI:10.12015/issn.1674-8034.2025.08.021.


[Abstract] With the continuous deepening of research in the field of glucose metabolism disorders, prediabetes mellitus (PDM), as a critical stage in the development of diabetes, can lead to abnormalities in brain structure and function, increasing the risk of cognitive impairment and thus becoming a major public health issue urgently needing to be addressed in the current medical field of glucose metabolism disorders; at present, the pathophysiological mechanisms underlying PDM-induced abnormalities in brain tissue structure and function have not yet been fully clarified, and there is a lack of systematic research conclusions on its imaging characteristics, against which background the use of non-invasive MRI technology to achieve early diagnosis and intervention of PDM-related brain injury holds important clinical practical value; in recent years, MRI and its derivative technologies have gradually demonstrated irreplaceable and significant advantages in exploring the pathogenesis and clinical diagnosis of PDM-related brain injury, and this article systematically reviews the research progress on PDM-related changes in brain structure and function based on multimodal MRI techniques, while pointing out the limitations of current research and exploring future research directions, aiming to provide new insights for elaborating the pathological mechanisms of PDM-related cognitive impairment and optimizing clinical treatment decisions.
[Keywords] prediabetes mellitus；brain structure；magnetic resonance imaging；resting-state functional magnetic resonance imaging；diffusion tensor imaging；gray matter；white matter；glymphatic system

XIANG Yu1   YANG Siyi1   TIAN Bin2   HE Qing2   LI Shiguang1, 2*  

1 College of Medical Imaging, Guizhou Medical University, Guiyang 550004, China

2 Department of Imaging, the Second People's Hospital of Guiyang, Guiyang 550081, China

Corresponding author: LI S G, E-mail: imaging_shiguangli@163.com

Conflicts of interest   None.

Received  2025-05-15
Accepted  2025-08-08
DOI: 10.12015/issn.1674-8034.2025.08.021
DOI:10.12015/issn.1674-8034.2025.08.021.

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