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Research progress of MRI in blood-brain barrier injury associated with acute ischemic stroke
SHI Haoyang  QIAN Weiyun  WANG Kaifeng  MO Yongjia  GONG Weiyi 

DOI:10.12015/issn.1674-8034.2025.08.023.


[Abstract] Acute ischemic stroke (AIS) is one of the important diseases causing disability and death among Chinese residents. Blood brain barrier (BBB) injury plays a key role in the pathophysiology and disease progression of AIS. Due to the complexity of its molecular mechanism, research on BBB injury is still not in-depth enough. MRI has been widely applied in the diagnosis and pathological mechanism research of AIS and many other aspects. However, the imaging standards of various techniques still need to be further unified. This article will review the related mechanisms of AIS and BBB injury and the current research and application status of MRI-related techniques, discuss the advantages and disadvantages of different MRI techniques in the assessment of BBB injury, and aim to provide more basis and new ideas for the further development of early precise diagnosis, neuroprotective strategies and individualized clinical treatment of AIS in the future.
[Keywords] ischemic stroke；blood-brain barrier；magnetic resonance imaging；dynamic contrast enhancement imaging；dynamic susceptibility contrast imaging；arterial spin labeling

SHI Haoyang   QIAN Weiyun   WANG Kaifeng   MO Yongjia   GONG Weiyi*  

Department of Medical Imaging, Shengli Oilfield Central Hospital, Dongying 257034, China

Corresponding author: GONG W Y, E-mail: gve566@163.com

Conflicts of interest   None.

Received  2025-05-07
Accepted  2025-08-05
DOI: 10.12015/issn.1674-8034.2025.08.023
DOI:10.12015/issn.1674-8034.2025.08.023.

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