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Progress in MRI on brain imaging of patients with cervical spondylotic myelopathy
YI Jiayuan  HE Laichang 

DOI:10.12015/issn.1674-8034.2025.08.028.


[Abstract] Cervical spondylotic myelopathy (CSM) is the leading cause of spinal cord dysfunction in adults worldwide. Recent studies have indicated the potential for irreversible damage, neural repair, and reorganization processes in the superior median brain of CSM patients. Therefore, exploring the underlying pathophysiological mechanisms is imperative for advancing the identification, treatment, and other aspects of CSM. Currently, although several review articles have focused on imaging alterations in neural remodeling of CSM, there remains a lack of systematic collation and analysis of recent neuroimaging studies in this field. This paper summarizes and reviews recent studies that used MRI to investigate cerebral damage, repair, and reorganization in CSM patients across structural, functional, metabolic, and hemodynamic perfusion domains. We critically examine current methodological challenges and propose future research trajectories, aiming to establish an imaging-derived framework for deciphering CSM-related neurobiological mechanisms. Ultimately, this work seeks to pioneer non-invasive diagnostic strategies and stimulate novel therapeutic approaches.
[Keywords] spinal cord injury；cervical spondylotic myelopathy；magnetic resonance imaging；structural magnetic resonance imaging；resting-state functional magnetic resonance imaging；neuroimaging biomarkers

YI Jiayuan   HE Laichang*  

Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Corresponding author: HE L C, E-mail: laichang_he@163.com

Conflicts of interest   None.

Received  2025-04-15
Accepted  2025-08-05
DOI: 10.12015/issn.1674-8034.2025.08.028
DOI:10.12015/issn.1674-8034.2025.08.028.

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