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• Clinical Article •
Application of cardiac magnetic resonance tissue tracking and T1 mapping technology in the assessment of diabetic myocardial injury
PANG Yanqiu  WAN Na  GUO Rui  DENG Defeng  ZHOU Hao  ZHANG Kai  LAN Fang  MA Jing 

Cite this article as: PANG Y Q, WAN N, GUO R, et al. Application of cardiac magnetic resonance tissue tracking and T1 mapping technology in the assessment of diabetic myocardial injury[J]. Chin J Magn Reson Imaging, 2025, 16(9): 82-89. DOI:10.12015/issn.1674-8034.2025.09.013.


[Abstract] Objective To explore the application value of cardiac magnetic resonance tissue tracing (CMR-TT) and T1 mapping technology in the assessment of myocardial injury in patients with type 2 diabetes mellitus (T2DM).Materials and Methods A total of 64 patients with T2DM and 32 healthy controls (HC) who underwent cardiac magnetic resonance examination in our hospital from December 2023 to April 2025 were prospectively collected. All cardiac magnetic resonance image data were imported into special software for analysis, and the myocardial strain parameters, biventricular function parameters and left ventricular T1 mapping parameters were obtained, and the above parameters were compared between the two groups by t-test, Mann-Whitney U test and chi-square test, and the association between myocardial structure, function and myocardial strain was analyzed by Pearson and Spearman correlation.Results In the T2DM group, the left ventricular myocardial mass index (LVMI) and left ventricular remodeling index (LVRI) were increased (both P < 0.001), the global longitudinal peak strain in the left ventricle (LV GLS) and the global longitudinal strain of the right ventricle decreased (both P<0.05) and the absolute values of peak systolic strain rate of the left ventricle (LV PSSR), longitudinal LV PSSR and left ventricular peak strain rate (LV PDSR) in the T2DM group were decreased (all P < 0.019).The storage strain and cathete strain of the left atrium/right attrium (LA/RA) were decreased in patients with T2DM (both P < 0.001). The extracellular volume (ECV) of T2DM patients was higher than that of HC group (P < 0.001).Biventricular ejection fraction, end-systolic volume index were correlated with biventricular strain function (all P < 0.003). LVMI is correlated with the Global radial strain of the left ventricle (LV GRS), global circumferential strain of the left ventricle (LV GCS), LV GLS, circumferential LV PSSR, longitudinal LV PSSR, radial LV PDSR, circumferential LV PDSR, Longitudinal LV PDSR(all P < 0.021).The left ventricular end-diastolic volume index was correlated with LV GCS, LV GLS, circumferential LV PSSR, longitudinal LV PSSR, and circumferential LV PDSR (all P < 0.044). The right ventricular end-diastolic volume index was correlated with the global circumferential strain of the right ventricle (r = 0.331, P = 0.007). LVRI was correlated with LV GLS and longitudinal LV PDSR (both P < 0.01), and weakly correlated with radial LV PSSR (r = 0.266, P = 0.034).Conclusions Compared with the control group, the whole heart myocardial strain of T2DM patients is reduced, and the ECV value is higher. Biventricular myocardial structure, function and myocardial strain are interrelated. CMR-TT and T1 mapping techniques can effectively detect diabetic myocardial injury.
[Keywords] diabetes；diabetic cardiomyopathy；magnetic resonance imaging；cardiac magnetic resonance；tissue tracing；T1 mapping

PANG Yanqiu   WAN Na   GUO Rui   DENG Defeng   ZHOU Hao   ZHANG Kai   LAN Fang   MA Jing*  

Department of Radiology, Second Affiliated Hospital of Shihezi University School of Medicine/Xinjiang Production and Construction Corps Hospital, Urumqi 830000, China

Corresponding author: MA J, E-mail: missingshz@163.com

Conflicts of interest   None.

Received  2025-06-13
Accepted  2025-08-22
DOI: 10.12015/issn.1674-8034.2025.09.013
Cite this article as: PANG Y Q, WAN N, GUO R, et al. Application of cardiac magnetic resonance tissue tracking and T1 mapping technology in the assessment of diabetic myocardial injury[J]. Chin J Magn Reson Imaging, 2025, 16(9): 82-89. DOI:10.12015/issn.1674-8034.2025.09.013.

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