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Research progress of MRI in brain structure and function changes of obese patients after weight loss and metabolism surgery
JI Xiaoqi  LIU Ao  SUN Yongbing  ZHANG Xueyi  ZOU Zhi  LI Zhonglin  WU Xiaoling  ZHOU Jing  QIAN Liwei  WANG Yong  LIU Min  MA Xiao  HAO Yibin  LI Yongli 

DOI:10.12015/issn.1674-8034.2025.11.030.


[Abstract] Obesity is a chronic disease caused by abnormal or excessive accumulation of adipose tissue, which poses a significant health risk. Bariatric metabolic surgery (BMS), as an effective intervention for obesity, not only achieves long-term stable weight loss, but also induces dynamic remodeling of the central nervous system, which results in dynamic recovery of brain structures and reversible remodeling of limbic system functional pathways. In addition, BMS can contribute to weight loss and induce multidimensional brain functional remodeling through multiple mechanisms, such as reducing cravings for high-calorie foods, alleviating brain inflammation, and restoring neural signaling homeostasis. As a core non-invasive imaging technology, magnetic resonance imaging (MRI) plays an irreplaceable role in the field of neuroimaging. At present, there is a lack of review on the mechanism of brain structure and function remodeling after BMS surgery using multimodal MRI. Therefore, this study reviews the research results of multimodal MRI in recent years, analyzes the limitations of previous studies, and looks forward to the possible exploration direction in the future, aiming to explore the brain structure and function remodeling law of obese patients under BMS intervention, and provides a theoretical basis for the study of neurobiological mechanism and intervention strategy of obesity.
[Keywords] obesity；bariatric metabolic surgery；magnetic resonance imaging；functional magnetic resonance imaging；neuroimaging；brain remodeling

JI Xiaoqi1   LIU Ao1   SUN Yongbing1   ZHANG Xueyi1   ZOU Zhi2   LI Zhonglin2   WU Xiaoling3   ZHOU Jing4   QIAN Liwei5   WANG Yong6   LIU Min7   MA Xiao8   HAO Yibin9   LI Yongli4*  

1 Department of Medical Imaging, Zhengzhou University People's Hospital, Zhengzhou 450003, China

2 Department of Medical Imaging, Henan Provincial People's Hospital, Zhengzhou 450003, China

3 Department of Nuclear Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, China

4 Department of Health Management, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Chronic Disease, Zhengzhou 450003, China

5 Department of Hemangioma, Henan Provincial People's Hospital, Zhengzhou 450003, China

6 Department of General Practice, Henan Provincial People's Hospital, Zhengzhou 450003, China

7 Department of Hypertension, Henan Provincial People's Hospital, Zhengzhou 450003, China

8 Medical Examination Center, China-Japan Friendship Hospital, Beijing 100029, China

9 Hospital Offices, Henan Provincial People's Hospital, Zhengzhou 450003, China

Corresponding author: LI Y L,E-mail: shyliyongli@126.com

Conflicts of interest   None.

Received  2025-09-03
Accepted  2025-10-30
DOI: 10.12015/issn.1674-8034.2025.11.030
DOI:10.12015/issn.1674-8034.2025.11.030.

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