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Progress in research on central mechanisms of rs-fMRI in acupuncture treatment of Alzheimer's disease
XIE Wenting  LI Li  CHEN Yuzhu  WEI Yuting  MA Ling  YAN Xingke 

DOI:10.12015/issn.1674-8034.2025.12.026.


[Abstract] Alzheimer's disease (AD) is a disease characterized by progressive cognitive decline as the main clinical manifestation, which seriously affects patients' physical and mental health and social development. Acupuncture is one of the effective methods for treating AD, which can significantly improve AD symptoms and delay disease progression, but its central mechanism has not been fully clarified. Functional magnetic resonance imaging (fMRI) technology, with advantages such as no radiation, high temporal and spatial resolution, and high imaging clarity, provides a visual means for in-depth study of the central mechanism of acupuncture in the treatment of AD. By sorting out and summarizing the studies on the central mechanism of resting-state functional magnetic resonance imaging (rs-fMRI) in acupuncture treatment of AD, elaborates on the limitations of current research and points out the directions for future studies,this paper finds that AD patients have pathological manifestations such as structural damage in brain regions, abnormal functional connections between brain regions, and weakened connection effects of brain networks. Acupuncture can exert its role in treating AD by reducing structural damage in brain regions such as the hippocampus, temporal lobe, cingulate gyrus, and caudate nucleus, improving abnormal functional connections between brain regions such as the posterior cingulate gyrus, temporal lobe, parietal lobe, and frontal lobe, enhancing the connectivity effects of large-scale brain networks, including the default mode network (DMN), fronto-parietal network (FPN), central executive network (CEN), sensorimotor network (SMN), as well as the inter-network connectivity between the dorsal attention network (DAN) and DMN, so as to exert a therapeutic effect on AD, with the aim of providing a more comprehensive reference for the in-depth research on the central mechanism of acupuncture in the treatment of AD and the optimization of clinical protocols in the future.
[Keywords] Alzheimer's disease；acupuncture；resting-state functional magnetic resonance imaging；magnetic resonance imaging；central mechanism

XIE Wenting1   LI Li1   CHEN Yuzhu2   WEI Yuting1   MA Ling1   YAN Xingke1*  

1 School of Acupuncture and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, China

2 Department of Traditional Chinese Medicine, Medical College of Qinghai University, Xining 810016, China

Corresponding author: YAN X K, E-mail: yanxingke@126.com

Conflicts of interest   None.

Received  2025-07-24
Accepted  2025-10-24
DOI: 10.12015/issn.1674-8034.2025.12.026
DOI:10.12015/issn.1674-8034.2025.12.026.

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