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• Review •
Research progress on evaluating glymphatic system function in sleep disorder patients based on DTI-ALPS
WANG Yuzhu  CHEN Wen  YANG Bo 

DOI:10.12015/issn.1674-8034.2025.12.028.


[Abstract] Sleep disorders (SD) are closely linked to neurological diseases and cognitive decline, and their pathological mechanism may be related to dysfunction of the glymphatic system (GS). The GS clears metabolic waste from the brain through perivascular space(PVS) pathways, and sleep is considered a key physiological process regulating its function. In recent years, diffusion tensor imaging along the perivascular space (DTI-ALPS), as a non-invasive imaging technique, has been widely used to assess GS function and has demonstrated significant research value in the field of SD. This review summarizes the principles of DTI-ALPS and its latest research advances in SD, aiming to clarify the relationship between SD and GS function while providing valuable insights for future studies.
[Keywords] sleep disorder；glymphatic system；magnetic resonance imaging；diffusion tensor imaging analysis along the perivascular space

WANG Yuzhu1, 2   CHEN Wen1, 2   YANG Bo1*  

1 Department of Radiological Imaging Center, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China, Shiyan 442000, China

2 School of Biomedical Engineering, Hubei University of Medicine, Shiyan 442000, China

Corresponding author: YANG B, E-mail: yangbo@whu.edu.cn

Conflicts of interest   None.

Received  2025-08-29
Accepted  2025-11-27
DOI: 10.12015/issn.1674-8034.2025.12.028
DOI:10.12015/issn.1674-8034.2025.12.028.

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