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Research progress of magnetic resonance diffusion kurtosis imaging on the microstructure of white matter in patients with major depressive disorder
MAI Li  LI Xiaozhong  WU Dongyang  LI Yuning 

DOI:10.12015/issn.1674-8034.2026.01.021.


[Abstract] Depression is a severe mental disorder characterized by persistent low mood, loss of interest and anhedonia, accompanied by abnormal cognitive, behavioral and physiological functions. In severe cases, suicidal thoughts or behaviors may occur. The global prevalence rate is approximately 5%, resulting in a heavy socio-economic burden. Diffusion kurtosis imaging is a non-Gaussian diffusion technique based on water molecules, which can demonstrate the high heterogeneity of water molecule diffusion limitations and better study the white matter properties of complex fibrous regions, thereby obtaining the morphological parameters of nerve fibers. At present, most research on depression focuses on diffusion tensor imaging or brain gray matter, making it difficult to fully summarize the current research progress. This article mainly studies the correlation between the parameter values of diffusion kurtosis imaging and the changes in white matter of the brain and clinical symptoms in depression, and proposes future research directions,aimed at providing imaging evidence for the early diagnosis, disease monitoring and optimization of treatment plans of depression.
[Keywords] major depressive disorder；diffusion kurtosis imaging；magnetic resonance imaging；white matter；brain microstructure

MAI Li1   LI Xiaozhong2*   WU Dongyang1   LI Yuning1  

1 The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730000, China

2 Department of Radiology, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China

Corresponding author: LI X Z, E-mail: lixiaozhong925@163.com

Conflicts of interest   None.

Received  2025-08-12
Accepted  2025-12-09
DOI: 10.12015/issn.1674-8034.2026.01.021
DOI:10.12015/issn.1674-8034.2026.01.021.

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