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Research progress on MRI of the glymphatic system in mental disorders
LIU Zhaohui  LOU Tao  ZHANG Gaofeng 

Cite this article as: LIU Z H, LOU T, ZHANG G F. Research progress on MRI of the glymphatic system in mental disorders[J]. Chin J Magn Reson Imaging, 2026, 17(3): 104-109. DOI:10.12015/issn.1674-8034.2026.03.015.


[Abstract] In recent years, the discovery and further study of the glymphatic system (GS) has greatly advanced the field of neuroscience. The discovery of the GS has provided a new perspective on the mechanisms of metabolic waste removal in the central nervous system and fluid dynamics in the brain. When GS function is impaired, it can lead to the accumulation of neurotoxic substances such as amyloid-β (Aβ) and tau protein, as well as inflammatory mediators, interacting with sleep disturbances, neuroinflammation, and circadian rhythm disruptions, thereby influencing disease progression. The link between GS and disease originated in Alzheimer's disease, and research has gradually expanded to other fields, with growing evidence indicating that GS dysfunction is involved in the pathophysiological processes of various psychiatric disorders. However, research on GS in psychiatric disorders is still in its early stages, and some diseases remain underexplored in this field. This review systematically outlines the structure, function, and influencing factors of the GS, summarizes current imaging techniques used to assess GS function, discusses the limitations of existing research, and provides future perspectives. It aims to offer new insights into the intrinsic relationship between GS function and psychiatric disorders, and to serve as a reference for further research in this area.
[Keywords] glymphatic system；mental disorders；magnetic resonance imaging；aquaporin-4；astrocytes

LIU Zhaohui   LOU Tao   ZHANG Gaofeng*  

Department of Radiology, the Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China

Corresponding author: ZHANG G F, E-mail: zhanggaofeng159@126.com

Conflicts of interest   None.

Received  2026-01-03
Accepted  2026-03-09
DOI: 10.12015/issn.1674-8034.2026.03.015
Cite this article as: LIU Z H, LOU T, ZHANG G F. Research progress on MRI of the glymphatic system in mental disorders[J]. Chin J Magn Reson Imaging, 2026, 17(3): 104-109. DOI:10.12015/issn.1674-8034.2026.03.015.

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