Advances in magnetic resonance imaging research on post-stroke depression

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ZHANG Jigeng RU Luqing WANG Peng

Cite this article as: ZHANG J G, RU L Q, WANG P. Advances in magnetic resonance imaging research on post-stroke depression[J]. Chin J Magn Reson Imaging, 2026, 17(3): 139-148. DOI:10.12015/issn.1674-8034.2026.03.020.

Abstract

[Abstract] Post-stroke depression (PSD) is a prevalent and severe neuropsychiatric complication following stroke, which significantly compromises patients' functional recovery and quality of life. Current clinical assessment of PSD primarily relies on depression rating scales and medical history. However, these methods are limited by inherent subjectivity and challenges in early identification, and objective neuroimaging biomarkers remain scarce. Recent advancements in multimodal MRI have provided novel tools for the systematic characterization of brain structural, functional, and microstructural alterations associated with PSD. Nevertheless, existing findings are fragmented, and the interplay between different imaging modalities and their clinical translational value has not been systematically synthesized. By reviewing the research progress of structural MRI, functional MRI, diffusion MRI, and magnetic resonance spectroscopy (MRS) in PSD, this article highlights the potential of cross-scale multimodal integration in elucidating neural mechanisms and improving risk prediction. Furthermore, the current limitations and future directions of the field are analyzed. This review aims to provide a neuroimaging framework for objective assessment, biomarker exploration, and the development of precision intervention strategies for PSD.

[Keywords] post-stroke depression；magnetic resonance imaging；structural magnetic resonance imaging；functional magnetic resonance imaging；diffusion magnetic resonance imaging；magnetic resonance spectroscopy；multimodal magnetic resonance imaging

Contributor Information

ZHANG Jigeng RU Luqing WANG Peng^*

Department of Imaging, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230036, China

Corresponding author: WANG P, E-mail: peng615wang@163.com

Conflicts of interest None.

Publication Information

Received 2025-12-01

Accepted 2026-01-24

DOI: 10.12015/issn.1674-8034.2026.03.020

Text

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