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Research progress of deep learning combined with radiomics in musculoskeletal diseases
WEI Bingqi  LI Yijing  ZHANG Xinyue  LI Yuntan  ZHANG Luwei  YAO Qianwen  CHENG Shao  WANG Shangzeng 

Cite this article as: WEI B Q, LI Y J, ZHANG X Y, et al. Research progress of deep learning combined with radiomics in musculoskeletal diseases[J]. Chin J Magn Reson Imaging, 2026, 17(3): 213-220. DOI:10.12015/issn.1674-8034.2026.03.031.


[Abstract] Musculoskeletal diseases are among the most prevalent and debilitating chronic conditions worldwide. With the acceleration of population aging, their incidence continues to rise, posing a major public health challenge. Conventional imaging-based diagnosis relies heavily on the subjective interpretation of clinicians and is limited by high inter-observer variability, insufficient sensitivity for early lesions, and a lack of robust quantitative assessment tools, making it difficult to meet the requirements of precision medicine. In recent years, the rapid development of deep learning and radiomics has provided new technical pathways for intelligent assessment and decision-making in musculoskeletal disorders. This review systematically summarizes the research progress of deep learning and radiomics in a range of musculoskeletal conditions, including osteoarthritis, osteoporosis and fragility fractures, bone tumors and benign-malignant differentiation, muscle diseases and muscle atrophy, as well as tendon and ligament injuries. We focus on their applications in automatic segmentation, computer-aided diagnosis, disease classification, progression prediction, treatment decision support, and prognostic evaluation, highlighting their potential advantages in improving diagnostic accuracy, enabling quantitative characterization of lesions, and supporting individualized therapeutic strategies. In addition, we outline the major challenges currently limiting clinical translation, such as insufficient data standardization, limited model interpretability, suboptimal multicenter generalizability, and uncertainties in implementation pathways. Finally, future research directions are discussed with the aim of providing methodological reference and theoretical support for early diagnosis, prognostic assessment, and precision treatment of musculoskeletal diseases based on deep learning and radiomics.
[Keywords] musculoskeletal diseases;radiomics;deep learning;image segmentation;diagnosis;prognostic evaluation;magnetic resonance imaging

WEI Bingqi1, 2   LI Yijing3   ZHANG Xinyue3   LI Yuntan3   ZHANG Luwei1, 2   YAO Qianwen1, 2   CHENG Shao1, 2   WANG Shangzeng1, 2*  

1 School of Orthopedics, Henan University of Chinese Medicine, Zhengzhou 450002, China

2 Department of Orthopaedics, Henan Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou 450002, China

3 School of Traditional Chinese medicine, Henan University of Chinese medicine, Zhengzhou 450006, China

Corresponding author: WANG S Z, E-mail: wangsz74@163.com

Conflicts of interest   None.

Received  2025-11-29
Accepted  2026-01-31
DOI: 10.12015/issn.1674-8034.2026.03.031
Cite this article as: WEI B Q, LI Y J, ZHANG X Y, et al. Research progress of deep learning combined with radiomics in musculoskeletal diseases[J]. Chin J Magn Reson Imaging, 2026, 17(3): 213-220. DOI:10.12015/issn.1674-8034.2026.03.031.

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