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Research progress on the central mechanisms of acupuncture analgesia based on functional magnetic resonance imaging
LU Jinxian  YUAN Yuchun  WANG Ruirui  GUO Yiting  JIA Hongling  ZHANG Yongchen 

Cite this article as: LU J X, YUAN Y C, WANG R R, et al. Research progress on the central mechanisms of acupuncture analgesia based on functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2026, 17(4): 134-141. DOI:10.12015/issn.1674-8034.2026.04.019.


[Abstract] Pain is a complex multidimensional experience encompassing physiological, psychological, and social dimensions. Elucidating its mechanisms and achieving effective management remain persistent challenges in modern medicine. As an important non-pharmacological intervention, acupuncture analgesia has demonstrated unique advantages in clinical practice. In recent years, with the rapid development of brain science technology, functional magnetic resonance imaging (fMRI) has become a key tool for revealing the central neural mechanisms underlying acupuncture analgesia. Currently, research on the central mechanisms of acupuncture analgesia remains in its preliminary exploratory phase, facing challenges such as diverse methodological designs, high heterogeneity of findings, and insufficient integration of multimodal technologies. These limitations hinder the systematic synthesis of research outcomes and their clinical translation. This article systematically reviews the fMRI studies in acupuncture analgesia, focusing on both the immediate and cumulative analgesia effects. We examine how acupuncture modulates brain networks and functional connectivity, and summarize findings from task-based fMRI, resting-state fMRI, and multimodal MRI studies. The aim is to deepen the understanding of the biological mechanisms of acupuncture analgesia from an imaging perspective and to inform future research directions, thereby providing references for guiding clinical practice and facilitating translational applications.
[Keywords] acupuncture analgesia；functional magnetic resonance imaging；magnetic resonance imaging；central mechanisms；brain networks；neuroimaging

LU Jinxian1   YUAN Yuchun2   WANG Ruirui2   GUO Yiting2   JIA Hongling3   ZHANG Yongchen1*  

1 School of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250014, China

2 Department of Radiology, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China

3 Department of Acupuncture, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China

Corresponding author: ZHANG Y C, E-mail: zhangyc58@sina.com

Conflicts of interest   None.

Received  2025-12-11
Accepted  2026-03-12
DOI: 10.12015/issn.1674-8034.2026.04.019
Cite this article as: LU J X, YUAN Y C, WANG R R, et al. Research progress on the central mechanisms of acupuncture analgesia based on functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2026, 17(4): 134-141. DOI:10.12015/issn.1674-8034.2026.04.019.

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