Share:
Share this content in WeChat
X
Special Focus
Development status and prospect of liquid helium-free superconducting MRI technology: From resource dependence to independent controllability
YANG Fan  FU Haihong  YAN Dong  CHENG Xiaoguang 

DOI:10.12015/issn.1674-8034.2026.05.001.


[Abstract] Superconducting magnetic resonance imaging (MRI) stands as a cornerstone of modern medical diagnostic imaging, having long relied on liquid helium for cooling its superconducting magnets. However, the global scarcity and uneven distribution of helium resources, coupled with China's high external dependence on helium, severely constrain its widespread adoption and sustainable development.Helium-free MRI technology eliminates the traditional superconducting magnet's dependence on liquid helium. Utilizing direct conduction cooling as its core principle, it replaces the liquid helium bath with integrated cryocoolers to directly cool the superconducting coils. The maturation and widespread adoption of helium-free superconducting MRI technology hinge on systematically addressing engineering challenges related to its reliability, lifecycle cost-effectiveness, and extension to higher field strengths. This paper analyzes the driving forces behind helium-free MRI technological development, outlines the evolutionary path from "liquid-helium-based" to "low-liquid-helium" and finally to "cryogen-free" systems, and highlights the application prospects of helium-free MRI technology. The aim of this study is to provide strategic insights for China to overcome the "bottleneck" constraints in high-end medical equipment, build a self-sufficient and controllable medical equipment industry chain, and contribute Chinese perspectives and pathways to the green and sustainable development of global MRI technology.
[Keywords] helium-free;magnetic resonance imaging;superconducting magnet;helium resources

YANG Fan1   FU Haihong2   YAN Dong1   CHENG Xiaoguang1*  

1 Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China

2 Department of Radiology, Peking Union Medical College Hospital of Chinese Academy of Medical Sciences, Beijing 100730, China

Corresponding author: CHENG X G, E-mail: xiao65@263.net

Conflicts of interest   None.

Received  2026-01-26
Accepted  2026-05-10
DOI: 10.12015/issn.1674-8034.2026.05.001
DOI:10.12015/issn.1674-8034.2026.05.001.

[1]
EDELMAN R R. The history of MR imaging as seen through the pages of radiology[J/OL]. Radiology, 2014, 273(2Suppl): S181-S200 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/25340436/. DOI: 10.1148/radiol.14140706.
[2]
Central Committee of the Communist Party of China, State Council. Healthy China 2030 Planning Outline[Z]. 2016. https://www.gov.cn/zhengce/2016-10/25/content_5124174.htm.
[3]
Ministry of Industry and Information Technology, National Health Commission, National Development and Reform Commission, et al. 14th Five-Year Plan for the Development of the Medical Equipment Industry[Z]. NoDocument. Gong Xin Bu Lian Gui〔2021〕No. 208. 2021. https://www.miit.gov.cn/zwgk/.
[4]
U.S. Department of Commerce, Bureau of Industry and Security. Export Administration Regulations (EAR)[Z]. 2022. https://www.ecfr.gov/.
[5]
MANSO JIMENO M, VAUGHAN J T, GEETHANATH S. Superconducting magnet designs and MRI accessibility: a review[J/OL]. NMR Biomed, 2023, 36(9): e4921 [2026-01-25]. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.4921. DOI: 10.1002/nbm.4921.
[6]
TANG J R, ZHANG Y X, ZHOU J L, et al. Analysis of global helium industry chain and China's strategy[J]. Geol Bull China, 2023, 42(1): 1-13. DOI: 10.12097/j.issn.1671-2552.2023.01.001.
[7]
JIA L X, MA B, WANG H, et al. Progress and utilization status of global helium exploration and development[J]. Geol China, 2022, 49(5): 1427-1437. DOI: 10.12029/gc20220505.
[8]
HALPERIN W P. The impact of helium shortages on basic research[J]. Nat Phys, 2014, 10(7): 467-470. DOI: 10.1038/nphys3018.
[9]
USGS. Helium statistics and information[R]. United States Geologic Survey National Minerals Information Centre, 2021.
[10]
ANDERSON S T. Economics, helium, and the U.S. federal helium reserve: summary and outlook[J]. Nat Resour Res, 2018, 27(4): 455-477. DOI: 10.1007/s11053-017-9359-y.
[11]
LIU Q Y, LI P P, ZHU D Y, et al. Helium resource in the petroliferous basins in China and its development prospects[J/OL]. Cell Rep Phys Sci, 2024, 5(6): 102031 [2026-01-25]. https://www.cell.com/cell-reports-physical-science/fulltext/S2666-3864(24)00300-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS266638642400300X%3Fshowall%3Dtrue. DOI: 10.1016/j.xcrp.2024.102031.
[12]
BAI Y Y, GONG H J, WANG D X, et al. Distribution characteristics and controlling factors of helium in Yanchang exploration area of Ordos Basin[J]. Lithol Reserv, 2026, 38(3): 149-161. DOI: 10.12108/yxyqc.20260313.
[13]
LI J, WANG X B, XU Z S, et al. Helium resources accumulation regulations and their development prospects in China[J]. Nat Gas Geosci, 2024, 35(5): 851-868. DOI: 10.11764/j.issn.1672-1926.2024.04.027.
[14]
ZHANG W, LI Y H, WANG L, et al. The analysis of helium accumulation conditions and prediction of helium resource in Weihe Basin[J]. Nat Gas Geosci, 2018, 29(2): 236-244. DOI: 10.11764/j.issn.1672-1926.2017.12.002.
[15]
XU G, LI Y H, WANG Z Q, et al. Progress of investigation and evaluation of helium resources in China[J]. Acta Geol Sin, 2023, 97(5): 1711-1716. DOI: 10.19762/j.cnki.dizhixuebao.2023232.
[16]
LI Y H, ZHANG W, WANG L, et al. Several issues in the accumulation of crust-derived helium and the accumulation model[J]. J Xi'an Univ Sci Technol, 2017, 37(4): 565-572.
[17]
QIN S F, SUN Q S, YUE S C, et al. Overview of China's helium industry and its future development[J]. China Min Mag, 2025, 34(12): 1-14. DOI: 10.12075/j.issn.1004-4051.20252588.
[18]
LAVROVA A, MISHRA S, RICHARDSON J, et al. Quality assessment of routine brain imaging at 0.55 T: initial experience in a clinical workflow[J/OL]. NMR Biomed, 2024, 37(7): e5017 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/37654047/. DOI: 10.1002/nbm.5017.
[19]
GULANI V, KANDASAMY D, WEBB A G, et al. Expanding access to MRI: the role of all-purpose mid-field and 1.5-T scanners[J/OL]. Radiology, 2025, 316(3): e251406 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/40891980/. DOI: 10.1148/radiol.251406.
[20]
GRIGO J, MASITHO S, FAUTZ H P, et al. Usability of magnetic resonance images acquired at a novel low-field 0.55 T scanner for brain radiotherapy treatment planning[J/OL]. Phys Imaging Radiat Oncol, 2023, 25: 100412 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/36969504/. DOI: 10.1016/j.phro.2023.100412.
[21]
ALENEZI M M, ALQAHTANI S, ALQAHTANI H, et al. A narrative review of advancements in magnetic resonance imaging (MRI) technology: evaluating the shift from helium-cooled to helium-free systems[J/OL]. Cureus, 2025, 17(11): e96615 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/41399592/. DOI: 10.7759/cureus.96615.
[22]
YIN Z Y, BI L Y, SHI Y Q, et al. An economical and efficient helium recovery system for vibration-sensitive applications[J]. ACS Meas Sci Au, 2025, 5(2): 226-233. DOI: 10.1021/acsmeasuresciau.4c00097.
[23]
LI J, MENG Q, OUYANG Z, et al. Helium recovery and purification at CHMFL[J/OL]. IOP Conf Ser Mater Sci Eng, 2017, 171(1): 012012 [2026-01-25]. https://iopscience.iop.org/article/10.1088/1757-899X/171/1/012012. DOI: 10.1088/1757-899X/171/1/012012.
[24]
BARRIOS M, KYNOCH J. Helium recovery at the national high magnetic field laboratory[J/OL]. IOP Conf Ser: Mater Sci Eng, 2015, 101: 012103 [2026-01-25]. https://iopscience.iop.org/article/10.1088/1757-899X/101/1/012103. DOI: 10.1088/1757-899x/101/1/012103.
[25]
MICKE P, STARK J, KING S A, et al. Closed-cycle, low-vibration 4 K cryostat for ion traps and other applications[J/OL]. Rev Sci Instrum, 2019, 90(6): 065104 [2026-01-25]. https://pubs.aip.org/aip/rsi/article/90/6/065104/360416/Closed-cycle-low-vibration-4-K-cryostat-for-ion. DOI: 10.1063/1.5088593.
[26]
EßER M, PRATZER M, FRÖMMING M, et al. An ultra-high vacuum scanning tunneling microscope with pulse tube and Joule-Thomson cooling operating at sub-pm z-noise[J/OL]. Rev Sci Instrum, 2024, 95(12): 123703 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/39718408/. DOI: 10.1063/5.0230892.
[27]
COE A M, LI G H, ANDREI E Y. Cryogen-free modular scanning tunneling microscope operating at 4-K in high magnetic field on a compact ultra-high vacuum platform[J/OL]. Rev Sci Instrum, 2024, 95(8): 083702 [2026-01-25]. https://pubs.aip.org/aip/rsi/article-abstract/95/8/083702/3306681/Cryogen-free-modular-scanning-tunneling-microscope?redirectedFrom=fulltext. DOI: 10.1063/5.0212244.
[28]
SCHMIDT J A, SCHMIDT B, SPAGNA S, et al. Low input power 4 K pulse tube cryocooler driven by an inverter helium compressor: Intrinsic temperature oscillations and mechanical vibrations[J/OL]. Cryogenics, 2020, 108: 103085 [2026-01-25]. https://www.sciencedirect.com/science/article/pii/S0011227520300874?via%3Dihub. DOI: 10.1016/j.cryogenics.2020.103085.
[29]
LUO J P, YIN N, LU J B, et al. Design and construction of a refrigerator-cooled adiabatic calorimeter for heat capacity measurement in liquid helium temperature region[J/OL]. Rev Sci Instrum, 2024, 95(3): 035114 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/38466030/. DOI: 10.1063/5.0159807.
[30]
HAHN S, KIM K, KIM K, et al. 45.5-tesla direct-current magnetic field generated with a high-temperature superconducting magnet[J]. Nature, 2019, 570(7762): 496-499. DOI: 10.1038/s41586-019-1293-1.
[31]
ZHOU Y H, PARK D, IWASA Y. Review of progress and challenges of key mechanical issues in high-field superconducting magnets[J/OL]. Natl Sci Rev, 2023, 10(3): nwad001 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/37007748/. DOI: 10.1093/nsr/nwad001.
[32]
PROST M, RÖCKNER M E, TADAY R, et al. May bending radiographs be replaced by magnetic resonance imaging in patients with adolescent idiopathic scoliosis?[J]. Eur Spine J, 2023, 32(5): 1771-1776. DOI: 10.1007/s00586-023-07659-8.
[33]
PUGLIESI R A, CANNELLA R, VERNUCCIO F, et al. Pelvic floor dysfunction: Anatomical characterization and functional imaging with MRI defecography[J/OL]. Eur J Radiol, 2026, 196: 112706 [2026-01-25]. https://www.ejradiology.com/article/S0720-048X(26)00054-9/fulltext. DOI: 10.1016/j.ejrad.2026.112706.
[34]
CHO S M, KHANDUJA S, WILCOX C, et al. Clinical use of bedside portable ultra-low-field brain magnetic resonance imaging in patients on extracorporeal membrane oxygenation: results from the multicenter safe mri ecmo study[J]. Circulation, 2024, 150(24): 1955-1965. DOI: 10.1161/CIRCULATIONAHA.124.069187.
[35]
SHETH K N, MAZUREK M H, YUEN M M, et al. Assessment of brain injury using portable, low-field magnetic resonance imaging at the bedside of critically ill patients[J/OL]. JAMA Neurol, 2021, 78(1): 41 [2026-01-25]. https://jamanetwork.com/journals/jamaneurology/fullarticle/2769858. DOI: 10.1001/jamaneurol.2020.3263.
[36]
ZHU H W, CHEN H M J, ZENG L, et al. Portable head and neck magnetic resonance imaging device in neurosurgery[J]. Chin J Neuromed, 2023, 22(1): 58-63. DOI: 10.3760/cma.j.cn115354-20221028-00754.
[37]
KHANDUJA S, KANG J K, CHINEDOZI I D, et al. Ultra-low-field portable brain magnetic resonance imaging in patients with cardiac devices: current evidence and future directions[J]. ASAIO J, 2025, 71(4): 277-282. DOI: 10.1097/MAT.0000000000002368.
[38]
WALD L L, MCDANIEL P C, WITZEL T, et al. Low-cost and portable MRI[J]. J Magn Reson Imaging, 2020, 52(3): 686-696. DOI: 10.1002/jmri.26942.
[39]
LI X L, LIU Y H, QIAO S S, et al. Key technologies and development prospects of mobile low-field MRI devices[J]. Chin J Med Lnstrumentation, 2026, 50(1): 35-42. DOI: 10.12455/j.issn.1671-7104.250155.
[40]
CAI Y J. Application of network communication technology in mobile helium-free MRI equipment[J]. China New Technol New Prod, 2020(11): 36-37. DOI: 10.3969/j.issn.1673-9957.2020.11.017.
[41]
PARKINSON B J, BOULOUKAKIS K, SLADE R A. A compact 3 T all HTS cryogen-free MRI system[J/OL]. Supercond Sci Technol, 2017, 30(12): 125009 [2026-01-25]. https://iopscience.iop.org/article/10.1088/1361-6668/aa90b2. DOI: 10.1088/1361-6668/aa90b2.
[42]
MAJOROS M, SUMPTION M D, PARIZH M, et al. Magnetic, mechanical and thermal modeling of superconducting, whole-body, actively shielded, 3 T MRI magnets wound using MgB2 strands for liquid cryogen free operation[J/OL]. IEEE Trans Appl Supercond, 2022, 32(4): 4400104 [2026-01-25]. https://pubmed.ncbi.nlm.nih.gov/36245846/. DOI: 10.1109/tasc.2022.3147137.

PREV Research advances in multimodal imaging techniques for the evaluation of multi-organ damage in chronic mountain sickness
NEXT Impact of supine and upright positions on cerebral hydrodynamics in healthy subjects: A study using domestic multi-position helium-free MRI
  



Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn