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Research progress on resting-state functional magnetic resonance imaging in brain functional remodeling in patients with chronic insomnia
XU Hui  LIU Rongcheng  FAN Xuanqiang  XIE Yuchen  WANG Zhen  ZHOU Yunfeng  LI Mengmeng  ZHAO Chi 

Cite this article as XU H, LIU R C, FAN X Q, et al. Research progress on resting-state functional magnetic resonance imaging in brain functional remodeling in patients with chronic insomnia[J]. Chin J Magn Reson Imaging, 2026, 17(6): 140-146, 187. DOI:10.12015/issn.1674-8034.2026.06.018.


[Abstract] Chronic insomnia, a highly prevalent sleep disorder, is closely associated with brain functional reorganization. Resting-state functional magnetic resonance imaging (rs-fMRI), which relies on blood oxygen level-dependent signals, has emerged as a crucial technique for investigating brain functional reorganization in chronic insomnia due to its non-invasive nature and low cognitive load. Based on a review of recent rs-fMRI studies, this article found that patients with chronic insomnia exhibit multidimensional abnormal reorganization in regional brain function, functional connectivity, and functional networks. Furthermore, these abnormalities are closely linked to clinical symptoms and the gut microbiota. Current research still faces several limitations in methodological standardization, sample design, and clinical translation, which hinder the further application of research findings. In the future, optimizing research methodologies, deepening core research content, and expanding clinical translational value could help refine the theoretical framework of brain functional reorganization in chronic insomnia. Leveraging multimodal data may provide a more reliable theoretical basis and technical support for the early diagnosis and precise intervention.
[Keywords] chronic insomnia；magnetic resonance imaging；cerebral functional remodeling；functional connectivity；brain network

XU Hui1, 2   LIU Rongcheng3   FAN Xuanqiang1   XIE Yuchen4   WANG Zhen1   ZHOU Yunfeng1*   LI Mengmeng2   ZHAO Chi2  

1 Department of Tuina, College of Acupuncture and Tuina, Henan University of Chinese Medicine, Zhengzhou 450046, China

2 Department of Tuina, the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450003, China

3 MRI Room, the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450003, China

4 Department of Tuina, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450003, China

Corresponding author: ZHOU Y F, E-mail: zyf5680198@126.com

Conflicts of interest   None.

Received  2026-03-16
Accepted  2026-06-06
DOI: 10.12015/issn.1674-8034.2026.06.018
Cite this article as XU H, LIU R C, FAN X Q, et al. Research progress on resting-state functional magnetic resonance imaging in brain functional remodeling in patients with chronic insomnia[J]. Chin J Magn Reson Imaging, 2026, 17(6): 140-146, 187. DOI:10.12015/issn.1674-8034.2026.06.018.

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