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• Reviews •
Research progress of resting-state functional magnetic resonance imaging in post-stroke cognitive impairment
ZHU Jinyi  ZHAO Siyi  GU Lanxin  ZHANG Siqi  ZHANG Miao 

Cite this article as ZHU J Y, ZHAO S Y, GU L X, et al. Research progress of resting-state functional magnetic resonance imaging in post-stroke cognitive impairment[J]. Chin J Magn Reson Imaging, 2026, 17(8): 139-146, 153. DOI:10.12015/issn.1674-8034.2026.08.015.


[Abstract] Post-stroke cognitive impairment (PSCI) is one of the most common complications after stroke and has a significant impact on prognosis. The diagnosis of PSCI involves systematic assessments encompassing clinical symptoms, neuropsychological evaluations, and neuroimaging. Among these, resting-state functional magnetic resonance imaging (rs-fMRI) plays an important role in PSCI research. Rs-fMRI offers advantages such as non-invasiveness, lack of radiation exposure, and high sensitivity, making it well-suited for use in stroke populations. It can directly reflect post-stroke abnormalities in local neuronal activity, functional connectivity (FC) between brain regions, and brain network topological properties, thereby enabling objective assessment of the degree of cognitive impairment in PSCI patients. Consequently, rs-fMRI has been widely applied in studies investigating the neural mechanisms of PSCI, identifying therapeutic targets, and evaluating treatment efficacy. However, to date, there are very few literature reviews specifically focusing on rs-fMRI in PSCI. Existing studies remain limited to conventional analytical metrics, with insufficient depth and dimensionality of analysis, and a lack of systematic synthesis regarding the mechanisms underlying PSCI treatment. Therefore, this review summarizes the main findings and specific applications of rs-fMRI in PSCI research, analyzes current limitations, and proposes future research directions, aiming to provide new insights into the neural mechanisms of PSCI as well as clinical diagnosis and treatment decision-making.
[Keywords] post-stroke cognitive impairment；stroke；resting-state functional magnetic resonance imaging；research progress

ZHU Jinyi1   ZHAO Siyi1   GU Lanxin2   ZHANG Siqi3   ZHANG Miao3*  

1 Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China

2 Department of Rehabilitation, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China

3 Department of Acupuncture and Moxibustion, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China

Corresponding author: ZHANG M, E-mail: 13845088833@139.com

Conflicts of interest   None.

Received  2026-03-06
Accepted  2026-06-22
DOI: 10.12015/issn.1674-8034.2026.08.015
Cite this article as ZHU J Y, ZHAO S Y, GU L X, et al. Research progress of resting-state functional magnetic resonance imaging in post-stroke cognitive impairment[J]. Chin J Magn Reson Imaging, 2026, 17(8): 139-146, 153. DOI:10.12015/issn.1674-8034.2026.08.015.

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