Progress in multimodal cardiac magnetic resonance for the evaluation of myocardial injury in obese patients

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• Reviews •

CHEN Hong ZHOU Li TIAN Rong TANG Sishi FU Bing

Cite this article as CHEN H, ZHOU L, TIAN R, et al. Progress in multimodal cardiac magnetic resonance for the evaluation of myocardial injury in obese patients[J]. Chin J Magn Reson Imaging, 2026, 17(8): 168-176. DOI:10.12015/issn.1674-8034.2026.08.019.

Abstract

[Abstract] Obesity is a major risk factor for cardiovascular diseases. Myocardial injury induced by obesity can occur in patients with preserved left ventricular ejection fraction (LVEF). Early and accurate identification of such subclinical injuries is critical for preventing heart failure in obese individuals. However, conventional imaging modalities including ultrasound and computed tomography have notable limitations when applied to obese patients. Multimodal cardiac magnetic resonance (CMR), with the advantages of non-invasiveness and freedom from ionizing radiation, has emerged as a pivotal imaging tool and shows great potential in comprehensive myocardial evaluation. At present, there is a lack of systematic integration regarding the cross-sequence application value of multimodal CMR in assessing obesity-induced myocardial microcirculation disorders, myocardial strain abnormalities and metabolic dysfunction. Additionally, the dose-effect relationships between various CMR sequences and obesity-related myocardial injury remain unclear. This review comprehensively summarizes the research progress of multimodal CMR techniques, including cine imaging, late gadolinium enhancement (LGE), T1/T2 mapping, first-pass perfusion and myocardial spectroscopy, in assessing cardiac structure, myocardial strain, myocardial metabolism and myocardial microcirculation in obese patients. Current CMR studies on obesity-induced myocardial injury are predominantly single-center and single-sequence based. Although each of the above sequences has its own advantages, based on the analysis of the advantages and limitations of existing CMR approaches, we propose that future studies should focus on multi-center and multi-sequence design, the introduction of emerging technologies, and the promotion of multimodal imaging fusion. This review aims to provide an imaging reference for early risk stratification and dynamic efficacy monitoring of myocardial injury in obese patients.

[Keywords] obesity；myocardial injury；multimodal cardiac magnetic resonance；myocardial perfusion；myocardial strain；myocardial spectroscopy

Contributor Information

CHEN Hong¹ ZHOU Li² TIAN Rong² TANG Sishi³ FU Bing^3*

¹ School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China

² Department of General Surgery, Chengdu Fifth People's Hospital, Chengdu 611130, China

³ Department of Radiology, Chengdu Fifth People's Hospital, Chengdu 611130, China

Corresponding author: FU B, E-mail: 1125173278@qq.com

Conflicts of interest None.

Publication Information

Received 2026-03-20

Accepted 2026-07-12

DOI: 10.12015/issn.1674-8034.2026.08.019

Text

References

[1]

SINGH V, SUN J, CHENG S S, et al. Obesity as a chronic disease: a narrative review of evolving definitions, management strategies, and cardiometabolic prioritization[J]. Adv Ther, 2025, 42(11): 5341-5364. DOI: 10.1007/s12325-025-03352-y.

[2]

ALANSARI H, LAZZARA G, TAHA M B, ANTONIADES C, et al. The impact of obesity on cardiovascular diseases: heart failure[J]. Methodist DeBakey Cardiovasc J, 2025, 21(2): 44-52. DOI: 10.14797/mdcvj.1511.

[3]

KOSKINAS K C, VAN CRAENENBROECK E M, ANTONIADES C,et al. Obesity and cardiovascular disease: an ESC clinical consensus statement[J]. Eur Heart J, 2024, 45(38): 4063-4098. DOI: 10.1093/eurheartj/ehae508.

[4]

GOYAL A, CRABTREE C D, LEE B C, et al. The impact of severe obesity on image quality and ventricular function assessment in echocardiography and cardiac MRI[J]. Int J Cardiovasc Imaging, 2024, 40(5): 1081-1094. DOI: 10.1007/s10554-024-03078-y.

[5]

CIARAMELLA L, DI SERAFINO L, MITRANO L, et al. Invasive assessment of coronary microcirculation: a state-of-the-art review[J/OL]. Diagnostics (Basel), 2023, 14(1): 86 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/38201395/. DOI: 10.3390/diagnostics14010086.

[6]

KIKUCHI D S, QUINAGLIA T, BUKHARI S, et al. Cardiac magnetic resonance imaging in heart failure with preserved ejection fraction[J/OL]. Circ Cardiovasc Imaging, 2025, 18(9): e018519 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40843509/. DOI: 10.1161/CIRCIMAGING.125.018519.

[7]

INDIA F W M, KAJROLKAR A. Artificial intelligence in cardiac imaging: a comprehensive review of clinical implementation and validation[J/OL]. Premier J Cardiol, 2025 [2026-03-19]. https://premierscience.com/pjc-24-563/. DOI: 10.70389/pjc.100003.

[8]

BOLZ C, BLASZCZYK E, MAYR T, et al. Adiposity influences on myocardial deformation: a cardiovascular magnetic resonance feature tracking study in people with overweight to obesity without established cardiovascular disease[J]. Int J Cardiovasc Imaging, 2024, 40(3): 643-654. DOI: 10.1007/s10554-023-03034-2.

[9]

SHAO J W, CHEN B H, ABU-SHABAN K, et al. Epicardial adipose tissue in obesity with heart failure with preserved ejection fraction: Cardiovascular magnetic resonance biomarker study[J]. World J Cardiol, 2024, 16(3): 149-160. DOI: 10.4330/wjc.v16.i3.149.

[10]

HU M, LI B W, SONG Z W, et al. Advances in cardiac magnetic resonance imaging of cardiomyopathy associated with metabolic abnormalities[J]. Chin J Magn Reson Imaging, 2025, 16(8): 194-200. DOI: 10.12015/issn.1674-8034.2025.08.029.

[11]

MATUSIK P S, MIKRUT K, BRYLL A, et al. Cardiac magnetic resonance imaging in diagnostics and cardiovascular risk assessment[J/OL]. Diagnostics, 2025, 15(2): 178 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/39857062/. DOI: 10.3390/diagnostics15020178.

[12]

HADJ OTHMANE T EL, HADJ OTHMANE O EL, NIZAR H. Obesity-related phenotype of heart failure with preserved ejection fraction: a comprehensive review[J/OL]. Cureus, 2025 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40308410/. DOI: 10.7759/cureus.81512.

[13]

PEIKERT A, FONTANA M, SOLOMON S D, et al. Left ventricular hypertrophy and myocardial fibrosis in heart failure with preserved ejection fraction: mechanisms and treatment[J]. Eur Heart J, 2026, 47(1): 37-53. DOI: 10.1093/eurheartj/ehaf524.

[14]

LAVIE C J, LADDU D, ARENA R, et al. Healthy weight and obesity prevention[J]. J Am Coll Cardiol, 2018, 72(13): 1506-1531. DOI: 10.1016/j.jacc.2018.08.1037.

[15]

VACCA A, BROSOLO G, MARCANTE S, et al. Gut microbiota and short-chain fatty acids in cardiometabolic HFpEF: mechanistic pathways and nutritional therapeutic perspectives[J/OL]. Nutrients, 2026, 18(2): 321 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/41599934/. DOI: 10.3390/nu18020321.

[16]

CREA F. Cardiac magnetic resonance: challenges, opportunities, and developments[J]. Eur Heart J, 2022, 43(26): 2427-2431. DOI: 10.1093/eurheartj/ehac355.

[17]

LIU J, LI J, PU H X, et al. Cardiac remodeling and subclinical left ventricular dysfunction in adults with uncomplicated obesity: a cardiovascular magnetic resonance study[J]. Quant Imaging Med Surg, 2022, 12(3): 2035-2050. DOI: 10.21037/qims-21-724.

[18]

HENRY J A, ABDESSELAM I, DEAL O, et al. Changes in epicardial and visceral adipose tissue depots following bariatric surgery and their effect on cardiac geometry[J/OL]. Front Endocrinol, 2023, 14: 1092777 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/36761185/. DOI: 10.3389/fendo.2023.1092777.

[19]

LEWIS A J M, ABDESSELAM I, RAYNER J J, et al. Adverse right ventricular remodelling, function, and stress responses in obesity: insights from cardiovascular magnetic resonance[J]. Eur Heart J Cardiovasc Imaging, 2022, 23(10): 1383-1390. DOI: 10.1093/ehjci/jeab175.

[20]

SZABO L, MCCRACKEN C, COOPER J, et al. The role of obesity-related cardiovascular remodelling in mediating incident cardiovascular outcomes: a population-based observational study[J]. Eur Heart J Cardiovasc Imaging, 2023, 24(7): 921-929. DOI: 10.1093/ehjci/jeac270.

[21]

LIU J, LI J, YU J Q, et al. Regional fat distributions are associated with subclinical right ventricular dysfunction in adults with uncomplicated obesity[J/OL]. Front Cardiovasc Med, 2022, 9: 814505 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/35548430/. DOI: 10.3389/fcvm.2022.814505.

[22]

JIANG X Y, YU L Q, LI J Y, et al. Effect of obesity on cardiovascular morphofunctional phenotype: Study of Mendelian randomization[J/OL]. Medicine, 2025, 104(13): e41858 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40153760/. DOI: 10.1097/MD.0000000000041858.

[23]

PU Q, TANG L, PENG P F, et al. Left ventricular structural and functional changes in obese subjects with preserved left ventricular ejection fraction after bariatric surgery: assessment with cardiac magnetic resonance imaging[J]. J Sichuan Univ Med Sci, 2024, 55(6): 1410-1417. DOI: 10.12182/20241160503.

[24]

RAYNER J J, ABDESSELAM I, PAN J L, et al. Obesity and heart failure: exploring the cardiometabolic axis[J]. Cardiovasc Res, 2025, 121(8): 1173-1186. DOI: 10.1093/cvr/cvaf090.

[25]

LIU W J, LI S S, YU Y, et al. Differential cardiac remodeling in overweight and obesity: insights from noninvasive imaging[J]. Obes Facts, 2025, 18(6): 556-570. DOI: 10.1159/000546406.

[26]

BAI J Q, LI X L, SHI Z Z, et al. Changes in the structure, function, and fat content of the heart in patients with obesity after bariatric surgery: a prospective magnetic resonance imaging study[J]. Obes Surg, 2025, 35(1): 9-18. DOI: 10.1007/s11695-024-07254-w.

[27]

BRADY B, KING G, MURPHY R T, et al. Myocardial strain: a clinical review[J]. Ir J Med Sci 1971, 2023, 192(4): 1649-1656. DOI: 10.1007/s11845-022-03210-8.

[28]

ZLIBUT A, COJOCARU C, ONCIUL S, et al. Cardiac magnetic resonance imaging in appraising myocardial strain and biomechanics: a current overview[J/OL]. Diagnostics (Basel), 2023, 13(3): 553 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/36766658/. DOI: 10.3390/diagnostics13030553.

[29]

BUCIUS P, ERLEY J, TANACLI R, et al. Comparison of feature tracking, fast-senc, and myocardial tagging for global and semental left ventricular strain[J]. ESC Heart Fail, 2020, 7(2): 523-532. DOI: 10.1002/ehf2.12576.

[30]

DEAL O, RAYNER J, STRACQUADANIO A, et al. Effect of weight loss on early left atrial myopathy in people with obesity but No established cardiovascular disease[J/OL]. J Am Heart Assoc, 2022, 11(22): e026023 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/36346054/. DOI: 10.1161/JAHA.122.026023.

[31]

HOMSI R, YUECEL S, SCHLESINGER-IRSCH U, et al. Epicardial fat, left ventricular strain, and T1-relaxation times in obese individuals with a normal ejection fraction[J]. Acta Radiol, 2019, 60(10): 1251-1257. DOI: 10.1177/0284185119826549.

[32]

LIU J, LI J, XIA C C, et al. Diastolic dysfunction in adults with uncomplicated obesity evaluated with left atrial and left ventricular tissue tracking and ventricular volume-time curve: a prospective cardiac magnetic resonance study[J]. Quant Imaging Med Surg, 2024, 14(7): 5040-5056. DOI: 10.21037/qims-23-1785.

[33]

GOLDMAN S A, REQUENA-IBANEZ J A, DEVESA A, et al. Uncovering the role of epicardial adipose tissue in heart failure with preserved ejection fraction[J/OL]. JACC Adv, 2023, 2(9): 100657 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/38938732/. DOI: 10.1016/j.jacadv.2023.100657.

[34]

SONG Y J, NING T, CHEN M T, et al. Association of epicardial adipose tissue and biventricular strain in heart failure with preserved and reduced ejection fraction[J/OL]. J Cardiovasc Magn Reson, 2025, 27(2): 101935 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40825422/. DOI: 10.1016/j.jocmr.2025.101935.

[35]

MONTI C B, CODARI M, DE CECCO C N, et al. Novel imaging biomarkers: epicardial adipose tissue evaluation[J/OL]. Br J Radiol, 2020, 93(1113): 20190770 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/31782934/. DOI: 10.1259/bjr.20190770.

[36]

ZHANG Y, LIN X L, NIE P. Advances in imaging studies for assessing epicardial adipose tissue[J]. Comput Tomogr Theory Appl, 2025, 34(1): 1-7. DOI: 10.15953/j.ctta.2024.196.

[37]

LIU J, QU Y L, LI J, et al. Myocardial tissue remodeling in early adult obesity and its association with regional adipose tissue distribution and ectopic fat deposits: a prospective study[J]. Eur Radiol, 2024, 34(2): 970-980. DOI: 10.1007/s00330-023-10081-9.

[38]

ZHU L, GU S J, WANG Q R, et al. Left ventricular myocardial deformation: a study on diastolic function in the Chinese male population and its relationship with fat distribution[J]. Quant Imaging Med Surg, 2020, 10(3): 634-645. DOI: 10.21037/qims.2020.01.16.

[39]

PACKER M. Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium[J]. J Am Coll Cardiol, 2018, 71(20): 2360-2372. DOI: 10.1016/j.jacc.2018.03.509.

[40]

CACCIAPUOTI F. Epicardial adipose tissue as a cardiometabolic target in atrial fibrillation: implications for ablation strategies and emerging metabolic therapies[J/OL]. Med Sci (Basel), 2026, 14(1): 127 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/41892842/. DOI: 10.3390/medsci14010127.

[41]

AQUARO G D, DE GORI C, FAGGIONI L, et al. Diagnostic and prognostic role of late gadolinium enhancement in cardiomyopathies[J/OL]. Eur Heart JSuppl, 2023, 25(Suppl C): C130-C136 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/37125322/. DOI: 10.1093/eurheartjsupp/suad015.

[42]

MAKOWSKI M R, JANSEN C H P, EBERSBERGER U, et al. Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins[J]. Eur Radiol, 2017, 27(11): 4612-4618. DOI: 10.1007/s00330-016-4616-8.

[43]

WANG J, PU L T, ZHANG J Q, et al. Effect of obesity on myocardial tissue characteristics in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance-based study[J/OL]. J Cardiovasc Magn Reson, 2025, 27(1): 101903 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40320074/. DOI: 10.1016/j.jocmr.2025.101903.

[44]

THONGSONGSANG R, SONGSANGJINDA T, TANAPIBUNPON P, et al. Native T1 mapping and extracellular volume fraction for differentiation of myocardial diseases from normal CMR controls in routine clinical practice[J/OL]. BMC Cardiovasc Disord, 2021, 21(1): 270 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/34082703/. DOI: 10.1186/s12872-021-02086-3.

[45]

MAREY A, ALABDULLAH A, GHORAB H, et al. Extracellular volume fraction and native T1 mapping in diabetic cardiomyopathy: a comprehensive meta-analysis[J/OL]. BMC Cardiovasc Disord, 2025, 25(1): 70 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/39893360/. DOI: 10.1186/s12872-025-04496-z.

[46]

KAWEL-BOEHM N, HETZEL S J, AMBALE-VENKATESH B, et al. Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update[J/OL]. J Cardiovasc Magn Reson, 2025, 27(1): 101853 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/39914499/. DOI: 10.1016/j.jocmr.2025.101853.

[47]

KRUSZEWSKA J, CUDNOCH-JEDRZEJEWSKA A, CZARZASTA K. Remodeling and fibrosis of the cardiac muscle in the course of obesity-pathogenesis and involvement of the extracellular matrix[J/OL]. Int J Mol Sci, 2022, 23(8): 4195 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/35457013/. DOI: 10.3390/ijms23084195.

[48]

DONG X, STRUDWICK M, WANG W Y, et al. Impact of body mass index and diabetes on myocardial fat content, interstitial fibrosis and function[J]. Int J Cardiovasc Imaging, 2023, 39(2): 379-390. DOI: 10.1007/s10554-022-02723-8.

[49]

ZHAO H, HUANG R, JIANG M, et al. Myocardial tissue-level characteristics of adults with metabolically healthy obesity[J]. JACC Cardiovasc Imaging, 2023, 16(7): 889-901. DOI: 10.1016/j.jcmg.2023.01.022.

[50]

REN Y F, DU X J, LI M C, et al. CMR assessment of epicardial edipose tissue in relation to myocardial inflammation and fibrosis in patients with new-onset atrial arrhythmias after STEMI[J/OL]. BMC Cardiovasc Disord, 2025, 25(1): 34 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/39833688/. DOI: 10.1186/s12872-025-04486-1.

[51]

YANG E Y, GHOSN M G, KHAN M A, et al. Myocardial extracellular volume fraction adds prognostic information beyond myocardial replacement fibrosis[J/OL]. Circ Cardiovasc Imaging, 2019, 12(12): e009535 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/31838882/. DOI: 10.1161/CIRCIMAGING.119.009535.

[52]

VIDIANTI G T, ATMADIKOESOEMAH C A, ELEN E. Impact of pericardial fat volume on myocardial inflammation assessed by quantitative T2 relaxation time using cardiac magnetic resonance imaging[J/OL]. Eur Heart J Cardiovasc Imaging, 2026, 27(Supplement_1): jeaf367.449 [2026-03-19]. https://academic.oup.com/ehjcimaging/article/27/Supplement_1/jeaf367.449/8446262. DOI: 10.1093/ehjci/jeaf367.449.

[53]

FOTAKI A, VELASCO C, PRIETO C, et al. Quantitative MRI in cardiometabolic disease: From conventional cardiac and liver tissue mapping techniques to multi-parametric approaches[J/OL]. Front Cardiovasc Med, 2022, 9: 991383 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/36756640/. DOI: 10.3389/fcvm.2022.991383.

[54]

BOROS G A B, HUEB W, REZENDE P C, et al. Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping[J/OL]. Diabetol Metab Syndr, 2024, 16(1): 156 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/38982515/. DOI: 10.1186/s13098-024-01395-9.

[55]

CRANE J D, JOY G, KNOTT K D, et al. The impact of bariatric surgery on coronary microvascular function assessed using automated quantitative perfusion CMR[J]. JACC Cardiovasc Imaging, 2024, 17(11): 1305-1316. DOI: 10.1016/j.jcmg.2024.05.022.

[56]

SHARKA I, PANICHELLA G, GRIGORATOS C, et al. Myocardial perfusion imaging with cardiovascular magnetic resonance in nonischemic cardiomyopathies: an in-depth review of techniques and clinical applications[J/OL]. Medicina (Kaunas), 2025, 61(5): 875 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40428833/. DOI: 10.3390/medicina61050875.

[57]

ANDROULAKIS E, GEORGIOPOULOS G, AZZU A, et al. Reduced response to regadenoson with increased weight: an artificial intelligence-based quantitative myocardial perfusion study[J/OL]. J Cardiovasc Magn Reson, 2024, 26(2): 101066 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/39067701/. DOI: 10.1016/j.jocmr.2024.101066.

[58]

HOEK R, VAN DIEMEN P A, SOMSEN Y B O, et al. Myocardial perfusion imaging in advanced coronary artery disease[J/OL]. Eur J Clin Investigation, 2025, 55(7): e70024 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40099580/. DOI: 10.1111/eci.70024.

[59]

SOUZA A C D A H, ROSENTHAL M H, MOURA F A, et al. Body composition, coronary microvascular dysfunction, and future risk of cardiovascular events including heart failure[J]. JACC Cardiovasc Imaging, 2024, 17(2): 179-191. DOI: 10.1016/j.jcmg.2023.07.014.

[60]

MARKLEY R, DEL BUONO M G, MIHALICK V, et al. Abnormal left ventricular subendocardial perfusion and diastolic function in women with obesity and heart failure and preserved ejection fraction[J]. Int J Cardiovasc Imaging, 2023, 39(4): 811-819. DOI: 10.1007/s10554-022-02782-x.

[61]

SHAH S A, REAGAN C E, BRESTICKER J E, et al. Obesity-induced coronary microvascular disease is prevented by iNOS deletion and reversed by iNOS inhibition[J]. JACC Basic Transl Sci, 2023, 8(5): 501-514. DOI: 10.1016/j.jacbts.2022.11.005.

[62]

STOIBER L, SCHNACKENBURG B, GEBKER R, et al. CMR stress testing in a patient with morbid obesity (BMI 58 kg/m2) and suspected coronary artery disease[J/OL]. BMC Cardiovasc Disord, 2018, 18(1): 47 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/29506495/. DOI: 10.1186/s12872-018-0779-3.

[63]

SOGHOMONIAN A, DUTOUR A, KACHENOURA N, et al. Is increased myocardial triglyceride content associated with early changes in left ventricular function A 1H-MRS and MRI strain study[J/OL]. Front Endocrinol, 2023, 14: 1181452 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/37424866/. DOI: 10.3389/fendo.2023.1181452.

[64]

RAYNER J J, PETERZAN M A, WATSON W D, et al. Myocardial energetics in obesity: enhanced ATP delivery through creatine kinase with blunted stress response[J]. Circulation, 2020, 141(14): 1152-1163. DOI: 10.1161/CIRCULATIONAHA.119.042770.

[65]

YURISTA S R, CHEN S, EDER R A, et al. Mapping the unseen: in vivo CEST-MRI of creatine reveals improved cardiac energetics in subjects with obesity following bariatric surgery[J]. Obes Surg, 2023, 33(6): 1944-1948. DOI: 10.1007/s11695-023-06589-0.

[66]

CHEN H Y, GORDON J W, DWORK N, et al. Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2-13C] Pyruvate MR spectroscopy[J/OL]. medRxiv, 2023: 2023.10.16.23297053 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/37905131/. DOI: 10.1101/2023.10.16.23297053.

[67]

LEWIS A J M, DODD M S, SOURDON J, et al. Hyperpolarized 13C and 31P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment[J/OL]. NMR Biomed, 2024, 37(11): e5206 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/38994722/. DOI: 10.1002/nbm.5206.

[68]

BISSELL M M, RAIMONDI F, AIT ALI L, et al. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update[J/OL]. J Cardiovasc Magn Reson, 2023, 25(1): 40 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/37474977/. DOI: 10.1186/s12968-023-00942-z.

[69]

REITER G, REITER C, OVCINA I, et al. Four-dimensional flow MRI for a dynamic perspective on the heart and adjacent great vessels[J/OL]. Radiology, 2025, 316(2): e242972 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/40793945/. DOI: 10.1148/radiol.242972.

[70]

PARK S, ENGLUND E K, FUJIWARA T, et al. Comprehensive CMR evaluation including 4D flow-derived E/a vorticity ratio in overweight adults with and without type 2 diabetes mellitus[J/OL]. Cardiovasc Diabetol, 2025, 25(1): 7 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/41361416/. DOI: 10.1186/s12933-025-02999-9.

[71]

CETIN I, RAISI-ESTABRAGH Z, PETERSEN S E, et al. Radiomics signatures of cardiovascular risk factors in cardiac MRI: results from the UK biobank[J/OL]. Front Cardiovasc Med, 2020, 7: 591368 [2026-03-19]. https://pubmed.ncbi.nlm.nih.gov/33240940/. DOI: 10.3389/fcvm.2020.591368.

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