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• Clinical Article •
Altered intranetwork functional connectivity in Parkinson's disease: An independent component analysis study
WANG Yapeng  CUI Xiaofeng  ZHAO Beibei  HU Tao  LIN Bixia  LIANG Hengrui 

Cite this article as: WANG Y P, CUI X F, ZHAO B B, et al. Altered intranetwork functional connectivity in Parkinson's disease: An independent component analysis study[J]. Chin J Magn Reson Imaging, 2026, 17(9): 62-68. DOI:10.12015/issn.1674-8034.2026.09.009.


[Abstract] Objective To investigate alterations in intranetwork functional connectivity in Parkinson's disease (PD) based on independent component analysis (ICA).Materials and Methods In this prospective case-control study, resting-state functional magnetic resonance imaging (fMRI) data from 28 patients with PD and 32 healthy controls (HC) were preprocessed. ICA was performed to identify resting-state functional networks. Differences in intranetwork functional connectivity between the two groups were compared, and correlations between the functional connectivity strength of altered brain regions and Unified Parkinson's Disease Rating Scale Part Ⅲ (UPDRS Ⅲ) scores were analyzed.Results Compared with HC, patients with PD exhibited significantly decreased functional connectivity within the left paracentral lobule of the somatomotor network (SMN) (t = -5.21, PFWE-corr < 0.001), as well as within the right middle frontal gyrus (t = -4.71, PFWE-corr = 0.015) and right inferior parietal lobule (t = -4.68, PFWE-corr = 0.015) of the right frontoparietal network (RFPN). The functional connectivity strength of the left paracentral lobule was negatively correlated with the UPDRS Part Ⅲ score (r = -0.512, P = 0.005, q = 0.015), whereas no significant correlations were observed between the UPDRS Part Ⅲ score and the functional connectivity strengths of the right middle frontal gyrus (r = 0.049, P = 0.805, q = 0.805) or the right inferior parietal lobule (r = 0.115, P = 0.560, q = 0.805).Conclusions Reduced functional connectivity within the SMN was associated with motor symptom severity in patients with PD, whereas the clinical implications of reduced functional connectivity within the RFPN remain to be further elucidated.
[Keywords] Parkinson's disease；brain network；functional connectivity；magnetic resonance imaging；independent component analysis；correlation analysis

WANG Yapeng1   CUI Xiaofeng2   ZHAO Beibei3*   HU Tao1   LIN Bixia1   LIANG Hengrui1  

1 The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen 518100, China

2 Department of Acupuncture and Moxibustion, Bao'an Traditional Chinese Medicine Hospital, Shenzhen 518100, China

3 Department of Rehabilitation, Bao'an Traditional Chinese Medicine Hospital, Shenzhen 518100, China

Corresponding author: ZHAO B B, E-mail: 64699609@qq.com

Conflicts of interest   None.

Received  2026-03-10
Accepted  2026-07-30
DOI: 10.12015/issn.1674-8034.2026.09.009
Cite this article as: WANG Y P, CUI X F, ZHAO B B, et al. Altered intranetwork functional connectivity in Parkinson's disease: An independent component analysis study[J]. Chin J Magn Reson Imaging, 2026, 17(9): 62-68. DOI:10.12015/issn.1674-8034.2026.09.009.

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