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• Clinical Article •
Resting-state functional MRI study of post-stroke cognitive impairment based on multiparametric brain function analysis
ZHANG Yiyao  PAHATI Tuxunjiang  YIMURAN Subi  AINIKAERJIANG Aihemaiti  XU Rui  HANJIAERBIEKE Kukun  WANG Yunling 

Cite this article as: ZHANG Y Y, PAHATI T X J, YIMURAN S B, et al. Resting-state functional MRI study of post-stroke cognitive impairment based on multiparametric brain function analysis[J]. Chin J Magn Reson Imaging, 2026, 17(9): 69-74, 91. DOI:10.12015/issn.1674-8034.2026.09.010.


[Abstract] Objective To explore the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and voxel-mirrored homotopic connectivity (VMHC) during the resting state in patients with post-stroke cognitive impairment (PSCI), and to investigate their correlations with clinical indicators and neurocognitive assessment scales.Materials and Methods A total of 61 patients with PSCI admitted to the Department of Neurology of the First Affiliated Hospital of Xinjiang Medical University from June 2025 to December 2025 were enrolled. In addition, 50 community-dwelling healthy controls (HC) without a history of cognitive impairment were recruited. All participants underwent resting-state functional magnetic resonance imaging. A two-sample t-test was performed using the DPABI V8.2 software package to compare resting-state functional differences between the two groups and identify brain regions with significant differences. Using the AAL atlas, the fALFF, ReHo, and VMHC values of these regions were extracted, and correlation analyses were performed between these functional indicators and neurocognitive assessment scales.Results Compared with the HC group, PSCI group showed decreased fALFF values in left medial superior frontal gyrus, left inferior parietal lobule, and right angular gyrus. Decreased ReHo values were observed in left inferior parietal lobule, left middle frontal gyrus, right superior parietal lobule, and right postcentral gyrus. In addition, decreased VMHC values were found in bilateral postcentral gyri, bilateral middle temporal gyri, and bilateral angular gyri. Correlation analysis revealed that fALFF value of left inferior parietal lobule was negatively correlated with Montreal Cognitive Assessment (MoCA) scores (r = -0.29, P = 0.021). No significant correlations were found among fALFF, ReHo, or VMHC values of other brain regions and MoCA scores (P > 0.05).Conclusions This study demonstrated that PSCI patients exhibited alterations in fALFF, ReHo, and VMHC values in specific brain regions compared with healthy individuals. Moreover, fALFF value of left inferior parietal lobule was associated with cognitive performance. These findings provide new insights into potential neural mechanisms underlying functional brain alterations in PSCI patients.
[Keywords] post-stroke cognitive impairment；resting-state functional magnetic resonance imaging；fractional amplitude of low-frequency fluctuation；regional homogeneity；voxel-mirrored homotopic connectivity

ZHANG Yiyao   PAHATI Tuxunjiang   YIMURAN Subi   AINIKAERJIANG Aihemaiti   XU Rui   HANJIAERBIEKE Kukun   WANG Yunling*  

Department of Radiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China

Corresponding author: WANG Y L, E-mail: 1079806994@qq.com

Conflicts of interest   None.

Received  2026-04-12
Accepted  2026-08-10
DOI: 10.12015/issn.1674-8034.2026.09.010
Cite this article as: ZHANG Y Y, PAHATI T X J, YIMURAN S B, et al. Resting-state functional MRI study of post-stroke cognitive impairment based on multiparametric brain function analysis[J]. Chin J Magn Reson Imaging, 2026, 17(9): 69-74, 91. DOI:10.12015/issn.1674-8034.2026.09.010.

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