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Research progress of magnetic resonance proton density fat fraction in extra-hepatic fat quantification
KUANG Lanqiong  CHENG Yu  ZHU Yong  YANG Lixia 

Cite this article as: KUANG L Q, CHENG Y, ZHU Y, et al. Research progress of magnetic resonance proton density fat fraction in extra-hepatic fat quantification[J]. Chin J Magn Reson Imaging, 2026, 17(9): 199-206. DOI:10.12015/issn.1674-8034.2026.09.026.


[Abstract] Magnetic resonance proton density fat fraction (MR-PDFF) is a non-invasive, accurate and reproducible fat quantification technique. It has been widely applied in the research of hepatic fat metabolism and related diseases. However, fat metabolic disorders and ectopic fat deposition are not confined to the liver, they also involve multiple extra-hepatic tissues, including the pancreas, kidneys, vertebral bone marrow, paraspinal muscles and skeletal muscles, and are closely associated with the onset and progression of various metabolic, digestive, osteoarticular diseases and malignant tumors. This paper briefly describes the basic principles of MR-PDFF technology and systematically elaborates its application value and research progress in fat quantification of extra-hepatic tissues such as the pancreas, kidneys, vertebral bone marrow and muscles, so as to provide references for early screening, mechanistic research and precise diagnosis and treatment of extra-hepatic fat-related diseases.
[Keywords] magnetic resonance imaging；fat fraction；proton density；pancreas；kidney；vertebral bone marrow；muscle

KUANG Lanqiong1   CHENG Yu2   ZHU Yong1   YANG Lixia1*  

1 Department of Radiology, Zhongshan-Xuhui Hospital, Fudan University, Shanghai 200237, China

2 Department of Radiology, Children's Hospital of Fudan University, Shanghai 201102, China

Corresponding author: YANG L X, E-mail: cocoding@sina.com

Conflicts of interest   None.

Received  2026-01-09
Accepted  2026-08-23
DOI: 10.12015/issn.1674-8034.2026.09.026
Cite this article as: KUANG L Q, CHENG Y, ZHU Y, et al. Research progress of magnetic resonance proton density fat fraction in extra-hepatic fat quantification[J]. Chin J Magn Reson Imaging, 2026, 17(9): 199-206. DOI:10.12015/issn.1674-8034.2026.09.026.

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