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• Clinical Article •
Value of a multiparametric MRI model incorporating T1 mapping, T2 mapping, and DKI for differential diagnosis of salivary gland tumors
ZHANG Zirui  SHAO Shuo  YANG Huan  WANG Ning  PANG Guoxun  ZHENG Ning 

Cite this article as: Citation:ZHANG　Z R, SHAO　S, YANG　H, et al. Value of a multiparametric MRI model incorporating T1 mapping, T2 mapping, and DKI for differential diagnosis of salivary gland tumors[J]. Chin J Magn Reson Imaging, 2026, 17(10): 84-93. DOI:10.12015/issn.1674-8034.2026.10.010.


[Abstract] Objective To evaluate the diagnostic value of quantitative parameters derived from T1-mapping, T2-mapping, and diffusion kurtosis imaging (DKI), as well as their combined models, in differentiating common salivary gland tumor types [pleomorphic adenoma (PA), Warthin tumor (WT), and malignant tumor (MT)], and to explore their optimal diagnostic thresholds.Materials and Methods This study was registered in the Medical Research Registration and Filing Information System of the National Health Commission (Filing No. MR-37-26-035352). A retrospective analysis was conducted on 78 patients with pathologically confirmed salivary gland tumors (SGTs) who were treated at Jining First People's Hospital between March 2024 and November 2025 and met the eligibility criteria. The patient cohort included 16 cases of MT, 35 cases of PA, and 27 cases of WT. All patients underwent MRI examinations, including T1 mapping, T2 mapping, and DKI sequences. Quantitative parameters [T1, T2, mean diffusivity (MD), and mean kurtosis (MK)] were compared across the three groups, and the discriminatory ability of individual parameters and combined logistic regression models was evaluated using receiver operating characteristic (ROC) curve analysis.Results Compared with WT, PA had higher T1, T2, and MD values (t = 4.315, P = 0.002; Z = -6.140, Z = -4.671, respectively; all P < 0.001), but lower MK values (t = -7.850, P < 0.001), the difference was statistically significant. Compared with MT, PA had higher T2 and MD values (Z = -4.304, P < 0.001; Z = -3.167, P = 0.002), while MT had higher MK values than PA (t = -4.754, P < 0.001), the difference was statistically significant. However, the difference in T1 values between PA and MT was not statistically significant (t = -0.116, P = 0.920). Furthermore, the T1 and T2 values of WT were both lower than those of MT (t = -4.651, Z = -3.291, respectively; both P ≤ 0.001), the difference was statistically significant; while the differences in MD and MK values were not statistically significant (Z = -0.892, P = 0.372; t = 1.266, P = 0.213). By combining multiple parameters using logistic regression, the resulting models achieved AUC ranging from 0.732 (95% CI: 0.606 to 0.858) to 0.993 (95% CI: 0.979 to 1.000); among them, the T1_T2_MD_MK combined model demonstrated the best performance in differentiating PA from WT (AUC = 0.993, 95% CI: 0.979 to 1.000).Conclusions Quantitative parameters derived from T1 mapping, T2 mapping, and DKI show good value in differentiating PA from WT. The combined T1_T2_MD_MK model integrating all three parameters achieved the best performance (AUC = 0.993) in distinguishing PA from WT, which may assist preoperative differentiation between these two types of tumors with markedly different treatment strategies and provide imaging evidence for individualized surgical planning. Findings involving MT are exploratory and warrant further validation.
[Keywords] salivary gland tumors；magnetic resonance imaging；T1 mapping；T2 mapping；diffusion kurtosis imaging；quantitative parameters

ZHANG Zirui1   SHAO Shuo2   YANG Huan2   WANG Ning2   PANG Guoxun2   ZHENG Ning2*  

1 Shandong Second Medical University, Weifang 261000, China

2 Department of Radiology, Jining No.1 People's Hospital, Jining 272000, China

Corresponding author: ZHENG N, E-mail: zhengning_369@163.com

Conflicts of interest   None.

Received  2026-05-16
Accepted  2026-08-23
DOI: 10.12015/issn.1674-8034.2026.10.010
Cite this article as: Citation:ZHANG　Z R, SHAO　S, YANG　H, et al. Value of a multiparametric MRI model incorporating T1 mapping, T2 mapping, and DKI for differential diagnosis of salivary gland tumors[J]. Chin J Magn Reson Imaging, 2026, 17(10): 84-93. DOI:10.12015/issn.1674-8034.2026.10.010.

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