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• Original Article •
Quantitative assessment of myocardial tissue characteristics using intravoxel incoherent motion in a minipig model of acute myocardial infarction induced by transcatheter embolization
SONG Hui  LI Dongxue  LIU Xinfeng  LIAO Dan  WU Shuguang  WANG Rongpin 

Cite this article as: SONG H, LI D X, LIU X F, et al. Quantitative assessment of myocardial tissue characteristics using intravoxel incoherent motion in a minipig model of acute myocardial infarction induced by transcatheter embolization[J]. Chin J Magn Reson Imaging, 2026, 17(10): 134-141. DOI:10.12015/issn.1674-8034.2026.10.016.


[Abstract] Objective To investigate the feasibility of intravoxel incoherent motion (IVIM) imaging for quantitatively characterizing myocardial tissue in a minipig model of acute myocardial infarction (AMI) established by interventional embolization.Materials and Methods Ten healthy Guizhou minipigs were enrolled. IVIM imaging was performed before and after left circumflex artery (LCX) occlusion. The slow diffusion coefficient (D, ADCslow), fast perfusion coefficient (D*, ADCfast) and perfusion fraction (f) were measured in normal, infarcted and peri-infarct myocardium. Differences in these parameters among the three regions were compared, and their diagnostic performance was analyzed.Results A total of 48 image slices were acquired, among which 25 slices met the quality criteria, yielding a success rate of 52.1%. Univariate analysis showed that heart rate was significantly lower in the successful group than in the failure group, suggesting heart rate may affect image success rate (P < 0.05). The overall differences in D* and f among the three myocardial regions were statistically significant (P < 0.05). Post-hoc comparisons revealed that D* differed significantly between normal and infarcted myocardium, as well as between infarcted and peri-infarct myocardium (P < 0.001). The f in the infarcted region was significantly lower than that in normal and peri-infarct myocardium (P = 0.011), while no significant difference in f was found between normal and peri-infarct myocardium (P = 0.152). No significant intergroup difference in D was observed in overall or pairwise comparisons (P > 0.05). The receiver operating characteristic curve analysis showed that the area under the curve (AUC) of combined D* and f, D*, f, and D was 0.827, 0.806, 0.758 and 0.562, respectively.Conclusions Experiments based on this embolization-induced minipig model of acute myocardial infarction suggest that IVIM-derived D* and f values can reflect early myocardial injury and microcirculatory perfusion alterations. The combination of these parameters exhibits favorable diagnostic performance in distinguishing infarcted myocardium from the peri-infarct myocardium. However, given the inherent limitations of the animal model, the suboptimal reproducibility of D*, the small sample size, and the modest image acquisition success rate, these findings should be interpreted with caution and cannot be directly extrapolated to clinical practice.
[Keywords] acute myocardial infarction；microcirculation；minipig；magnetic resonance imaging；intravoxel incoherent motion

SONG Hui1   LI Dongxue2, 3   LIU Xinfeng2, 3   LIAO Dan2, 3   WU Shuguang4   WANG Rongpin2, 3*  

1 Department of Radiology, Dazu Hospital of Chongqing Medical University, Chongqing 402360, China

2 Department of Radiology, Guizhou Provincial People's Hospital, Guiyang 550002, China

3 Key Laboratory of Intelligent Medical Image Analysis and Precision Diagnosis in Guizhou Province, Guiyang 550002, China

4 Animal Research Institute, Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China

Corresponding author: WANG R P, E-mail: wangrongpin@126.com

Conflicts of interest   None.

Received  2026-05-28
Accepted  2026-09-20
DOI: 10.12015/issn.1674-8034.2026.10.016
Cite this article as: SONG H, LI D X, LIU X F, et al. Quantitative assessment of myocardial tissue characteristics using intravoxel incoherent motion in a minipig model of acute myocardial infarction induced by transcatheter embolization[J]. Chin J Magn Reson Imaging, 2026, 17(10): 134-141. DOI:10.12015/issn.1674-8034.2026.10.016.

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