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Advances in neuroimaging studies of acupuncture for Alzheimer's disease
LI Li  ZHAO Yaru  WANG Yan  XIE Wenting  ZHANG Renzhen  MA Cui  WEI Yuting  YAN Xingke 

Cite this article as: LI L, ZHAO Y R, WANG Y, et al. Advances in neuroimaging studies of acupuncture for Alzheimer’s disease[J]. Chin J Magn Reson Imaging, 2026, 17(10): 173-181. DOI:10.12015/issn.1674-8034.2026.10.021.


[Abstract] Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment and represents the most common cause of dementia. Acupuncture has been used as a therapeutic approach for AD and has shown potential in alleviating AD-related symptoms and delaying disease progression. Neuroimaging techniques provide objective and quantifiable evidence for elucidating the central mechanisms underlying acupuncture effects in AD. However, existing studies have predominantly focused on functional magnetic resonance imaging, and a systematic synthesis and comprehensive analysis from a multimodal neuroimaging perspective remain lacking regarding the objective effects of acupuncture in the treatment of AD, the key brain regions involved, the patterns of brain network modulation, and the underlying mechanisms. Therefore, we systematically summarize neuroimaging advances in acupuncture intervention for AD, focusing on magnetic resonance imaging modalities, including structural MRI, functional MRI, diffusion tensor imaging, arterial spin labeling, and magnetic resonance spectroscopy, as well as positron emission tomography and functional near-infrared spectroscopy. We synthesize findings related to brain structure, functional activity and connectivity, cerebral metabolism, and cerebral blood flow/perfusion, and discuss AD-related intracerebral alterations and the putative central regulatory mechanisms of acupuncture from a multidimensional perspective. This review aims to provide a reference for future studies and to facilitate further mechanistic and clinical research in this field.
[Keywords] Alzheimer's disease；acupuncture；neuroimaging；magnetic resonance imaging；positron emission tomography；functional near-infrared spectroscopy

LI Li1   ZHAO Yaru1   WANG Yan1   XIE Wenting1   ZHANG Renzhen1   MA Cui1   WEI Yuting1, 2   YAN Xingke1, 2*  

1 College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, China

2 Gansu Provincial Research Center for Traditional Chinese Medicine, Lanzhou 730000, China

Corresponding author: YAN X K, E-mail: yanxingke@126.com

Conflicts of interest   None.

Received  2026-04-25
Accepted  2026-07-15
DOI: 10.12015/issn.1674-8034.2026.10.021
Cite this article as: LI L, ZHAO Y R, WANG Y, et al. Advances in neuroimaging studies of acupuncture for Alzheimer’s disease[J]. Chin J Magn Reson Imaging, 2026, 17(10): 173-181. DOI:10.12015/issn.1674-8034.2026.10.021.

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