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• IVIM Papers •
Application of artery spin labeling and intravoxel incoherent motion MR study in the grading of gliomas
QU Yuan  JIANG Jie  QUAN Guang-nan 

DOI:10.12015/issn.1674-8034.2017.04.002.


[Abstract] Objective: To evaluate the diagnostic value of combining 3D artery spin labeling and intravoxel incoherent motion in grading of cerebral gliomas.Materials and Methods: A total of 32 patients with histopathology proved gliomas (13 low grade, 19 high grade) were included in this study. 3D ASL and multi-b IVIM images were retrospectively analyzed. The ASL and IVIM data were processed on workstation to get the CBF and D, D*, f values. The results were compared among high grade and low grade groups and P<0. 05 was regarded as statistically significant.Results: CBF were significantly higher in high grade gliomas than lower grade gliomas [(75.6±12.3) ml/(100g•min), (55.8±8.9) ml/(100g•min), respectively; P<0.001]. In bi-exponential IVIM model, the high grade gliomas of D* value also showed significantly higher than lower grade gliomas group [(40.3±23.5)×10-3 mm2/s, (19.2±7.5)×10-3 mm2/s, respectively; P<0.01)], but there had no difference of D [(0.73±0.26)×10-3 mm2/s, (0.59±0.15)×10-3 mm2/s, respectively; P>0.05)] and f (11.1±6.9, 7.2±4.1, respectively; P>0.05). The area under AUC of combination of CBF and D* for glioma grading was 0.935 and corresponding diagnostic sensitivity and specificity were 91.5% and 89.6%.Conclusion: The combination of 3D ASL and IVIM parameters can be used to differentiate high grade glioma and low grade glioma. Combination of CBF and D* value obtain better diagnostic performance than other parameters.
[Keywords] Glioma；Artery spin labeling；Intravoxel incoherent motion；Magnetic resonance imaging；Neoplasm grading

QU Yuan Department of MR, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi 830001, China

JIANG Jie* Department of MR, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi 830001, China

QUAN Guang-nan GE Healthcare, Beijing 100176, China

*Correspondence to: Jiang J, E-mail: quer_1@163.com

Conflicts of interest   None.

Received  2017-02-03
Accepted  2017-03-23
DOI: 10.12015/issn.1674-8034.2017.04.002
DOI:10.12015/issn.1674-8034.2017.04.002.

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