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• Clinical Article •
A functional connectivity strengths study in temporal lobe epilepsy based on resting-state fMRI
FANG Kun  SHEN Jun-lin  WANG Jun-ping  LI Wei 

DOI:10.12015/issn.1674-8034.2017.06.002.


[Abstract] Objective: Voxel-based whole brain functional connectivity strengths (FCS) map was used to investigate resting-state functional MRI (rs-fMRI) brain network abnormalities in patients with temporal lobe epilepsy (TLE).Materials and Methods: 30 patients with TLE and age, gender and years of education matched 27 normal controls (NC) were included to take rs-fMRI examination and behavioral assessment. The rs-fMRI data were processed and FCS maps were calculated. The differences of clinical basic data of groups, such as age, yeas of education, and the differences of neuropsychological test results were compared between the two groups by using two-sample t test. In addition, the differences in gender between the two groups were compared by Chi-squared test. General linear model was used to compare the FCS difference between TLE group and NC group. Linear correlation analysis was used to evaluate the relationship between cognitive function score between FCS values of brain regions with group differences in TLE patients.Results: Compared to NC group, TLE group had significantly decreased FCS values in brain regions including left superior temporal gyrus, right superior temporal gyrus, right superior frontal gyrus and right middle frontal gyrus (P<0.05, FDR corrected). FCS values in the right superior frontal gyrus was correlated negatively with the Beck Depression Inventory scores (r=-0.433, P=0.024), In addition, FCS values in the left superior temporal gyrus was negatively correlated with the State-Trait Anxiety Inventory scores (r= -0.434, P=0.024).Conclusion: These findings suggest multiple brain regions of the whole brain functional connectivity strengths significantly decrease in TLE patient, which may help to further reveal the neural mechanism of temporal lobe epilepsy.
[Keywords] Epilepsy, temporal lobe；Magnetic resonance imaging, functional；Functional connectivity

FANG Kun Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

SHEN Jun-lin Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

WANG Jun-ping Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

LI Wei* Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China

*Correspondence to: Li W, E-mail: 18622621188 @163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81601476
Received  2017-04-07
Accepted  2017-05-10
DOI: 10.12015/issn.1674-8034.2017.06.002
DOI:10.12015/issn.1674-8034.2017.06.002.

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