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Electrophysiological and fMRI research of grid cells
WANG Xin  WU Wen-bo  LI Zhu  WANG Tao  ZHANG Xin  QING Zhao  ZHANG Bing 

DOI:10.12015/issn.1674-8034.2018.05.011.


[Abstract] Since 2005, grid cells have been found in the entorhinal cortex in varied mammals. Grid cells, as the cytological basis of spatial navigation, have hexagonally arranged firing fields and play the role of path integration. Previous studies have been limited to animal level experiments and traumatic neurophysiological experiments. While more recently, grid cells have been identified also in human brain using functional MRI. Since found that grid cells participate in abstract cognitive processes more than spatial navigation, the role of grid cells in human cognition has attracted more and more attention. The decline of spatial navigation capability is the earliest sign of Alzheimer's disease. Exploring the neural mechanisms supporting spatial navigation remains a research hotspot in neuroscience. This article reviews the electrophysiological and fMRI research of grid cells.
[Keywords] Grid cells；Entorhinal cortex；Spatial navigation；Magnetic resonance imaging

WANG Xin Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

WU Wen-bo Department of Radiology, the Drum Tower Hospital Affiliated to the medical school of Nanjing University, Nanjing 210008, China

LI Zhu Medical School of Nanjing University, Nanjing 210093, China

WANG Tao College of physics, Nanjing University, Nanjing 210046, China

ZHANG Xin Department of Radiology, the Drum Tower Hospital Affiliated to the medical school of Nanjing University, Nanjing 210008, China

QING Zhao Department of Radiology, the Drum Tower Hospital Affiliated to the medical school of Nanjing University, Nanjing 210008, China

ZHANG Bing* Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

*Corresponding to: Zhang B, E-mail: zhangbing_nanjing@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  The Key International (Regional) Cooperation Projects of National Natural Science Foundation of China No.81720108022 The Senescence Special Cultivation Project in the Major Research Project of National Natural Science Foundation of China No. 91649116 The Social Development Project of the Provincial Natural Science Foundation of Jiangsu No. BE2016605
Received  2017-11-16
Accepted  2017-12-14
DOI: 10.12015/issn.1674-8034.2018.05.011
DOI:10.12015/issn.1674-8034.2018.05.011.

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