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Research progress of MRI neuroimaging in HIV-associated neurocognitive disorders
LI Ruili  LI Hongjun 

Cite this article as: Li RL, Li HJ. Research progress of MRI neuroimaging in HIV-associated neurocognitive disorders. Chin J Magn Reson Imaging, 2019, 10(6): 456-460. DOI:10.12015/issn.1674-8034.2019.06.013.


[Abstract] HIV can enter the central nervous system (CNS) soon after seroconversion (8 days) due to its neurotropic and cause persistent CNS damage. With ongoing injury to the brain, 50% of the infected individuals will progress to cognitive, behavioral and motor abnormalities, which are called HIV-associated neurocognitive disorders (HAND). While the more severe and progressive forms of HAND (HAD) are less prevalent due to cART, about 40% of HIV- infected patients continue to have two mild forms of HAND (ANI and MND). Cognitive impairment gradually worsens with the extension of the survival period. Diagnosis of HAND is mainly based upon an individual’s performance on multiple cognitive domains, which is time-consuming (3 hours). MRI is non-invasive and radiationless. Different neuroimaging sequences [diffusion tensor imaging (DTI), 3D T1WI, function MRI)] can be used to obtain the required information from different perspectives, to offer unique insight into early diagnosis and mechanisms underlying neuro HIV, to monitor disease progression, and to assist in evaluating the efficacy of particular cART regimens. We reviewed the progress of MRI neuroimaging in HAND.
[Keywords] acquired immunodeficiency syndrome；cognitive dysfunction；magnetic resonance imaging；brain structure；brain function

LI Ruili Department of Radiology, Beijing Youan Hospital, Capital Medical Universtiy, Beijing 100069, China

LI Hongjun* Department of Radiology, Beijing Youan Hospital, Capital Medical Universtiy, Beijing 100069, China

*Corresponding to: Li HJ, E-mail: lihongjun00113@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81771806 Capital Medical University Research and Incubation Funding No. PYZ2017124 Beijing Municipal Administration of Hospitals Incubating Program No. PX2016036
Received  2018-12-26
Accepted  2019-01-30
DOI: 10.12015/issn.1674-8034.2019.06.013
Cite this article as: Li RL, Li HJ. Research progress of MRI neuroimaging in HIV-associated neurocognitive disorders. Chin J Magn Reson Imaging, 2019, 10(6): 456-460. DOI:10.12015/issn.1674-8034.2019.06.013.

[1]
中国疾病预防控制中心，性病艾滋病预防控制中心，性病控制中心. 2018年第3季度全国艾滋病性病疫情. 中国艾滋病性病, 2018, 24(11): 1075.
[2]
Holt JL, Kraft-Terry SD, Chang L. Neuroimaging studies of the aging HIV-1-infected brain. J Neurovirol, 2012, 18(4): 291-302.
[3]
Luther VP, Wilkin AM. HIV infection in older adults. Clin Geriatr Med, 2007, 23(3): 567-583.
[4]
Justice AC, Modur SP, Tate JP, et al. Predictive accuracy of the veterans aging cohort study index for mortality with HIV infection: a North American cross cohort analysis. J Acquir Immune Defic Syndr, 2013, 62(2): 149-163.
[5]
Wyczechowska D, Lin HY, LaPlante A, et al. A miRNA Signature for cognitive deficits and alcohol use disorder in persons living with HIV/AIDS. Front Mol Neurosci, 2017, 10: 385
[6]
Antinori A, Arendt G, Becker JT, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology, 2007, 69(18): 1789-1799.
[7]
Heaton RK, Clifford DB, Franklin DR Jr, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study. Neurology, 2010, 75(23): 2087-2096.
[8]
Cysique LA, Jugé L, Gates T, et al. Covertly active and progressing neurochemical abnormalities in suppressed HIV infection. Neurol Neuroimmunol Neuroinflamm, 2018, 5(1): e430.
[9]
Ellero J, Lubomski M, Brew B. Interventions for neurocognitive dysfunction. Curr HIV/AIDS Rep, 2017, 14(1): 8-16.
[10]
Robertson K, Liner J, Meeker RB. Antiretroviral neurotoxicity. J Neurovirol, 2012, 18(5): 388-399.
[11]
Ferguson D, Clarke S, Berry N, et al. Attenuated SIV causes persisting neuroinflammation in the absence of a chronic viral load and neurotoxic antiretroviral therapy. AIDS, 2016, 30(16): 2439-2448.
[12]
Dennis EL, Thompson PM. Functional brain connectivity using fMRI in aging and alzheimer's disease. Neuropsychol Rev, 2014, 24(1): 49-62.
[13]
Zhu T, Zhong J, Hu R, et al. Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study. J Neurovirol, 2013, 19(1): 10-23.
[14]
Song SK, Sun SW, Ramsbottom MJ, et al. Dysmyelination revealed through MRI as increased radial diffusion of water. Neuroimage, 2002, 17(3): 1429-1436.
[15]
Hoare J, Fouche JP, Phillips N, et al. Clinical associations of white matter damage in cART-treated HIV-positive children in South Africa. J Neurovirol, 2015, 21(2): 120-128.
[16]
Ackermann C, Andronikou S, Saleh MG, et al. Early antiretroviral therapy in HIV-infected children is associated with diffuse white matter structural abnormality and corpus callosum sparing. AJNR Am J Neuroradiol, 2016, 37(12): 2363-2369.
[17]
Nakamoto BK, Jahanshad N, McMurtray A, et al. Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals. J Neurovirol, 2012, 18(4): 303-312.
[18]
Wang B, Liu Z, Liu J, et al. Gray and white matter alterations in early HIV-infected patients: Combined voxel-based morphometry and tract-based spatial statistics. J Magn Reson Imaging, 2016, 43(6): 1474-1483.
[19]
Gongvatana A, Cohen RA, Correia S, et al. Clinical contributors to cerebral white matter integrity in HIV-infected individuals. J Neurovirol, 2011, 17(5): 477-486.
[20]
Li R, Mi H, Zhao J, et al. White matter damage and effects of nadir CD4+ count on patients with asymptomatic HIV associated dementia complex-ADTI study. Radiol Infect Dis, 2014, 1(1): 11-16.
[21]
Tang Z, Liu Z, Li R, et al. Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data. Eur Radiol, 2017, 27(10): 4153-4162.
[22]
Li R, Tang Z, Mi H, et al. Diffusion tensor imaging study of early white matter integrity in HIV-infected patients: A tract-based spatial statistics analysis. Radiol Infect Dis, 2015, 2(4): 183-191.
[23]
Li J, Wu G, Wen Z, et al. White matter development is potentially influenced in adolescents with vertically transmitted HIV infections: A tract-based spatial statistics study. AJNR Am J Neuroradiol, 2015, 36(11): 2163-2169.
[24]
Ragin AB, Wu Y, Gao Y, et al. Brain alterations within the first 100 days of HIV infection. Ann Clin Transl Neurol, 2015, 2(1): 12-21.
[25]
Wright PW, Vaida FF, Fernandez RJ, et al. Cerebral white matter integrity during primary HIV infection. AIDS, 2015, 29(4): 433-442.
[26]
Pfefferbaum A, Rosenbloom MJ, Rohlfing T, et al. Frontostriatal fiber bundle compromise in HIV infection without dementia. AIDS, 2009, 23(15): 1977-1985.
[27]
Wright PW, Heaps JM, Shimony JS, et al. The effects of HIV and combination antiretroviral therapy on white matter integrity. AIDS, 2012, 26(12):1501-1508.
[28]
Aylward EH, Brettschneider PD, McArthur JC, et al. Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am J Psychiatry, 1995, 152(7): 987-994.
[29]
Stout JC, Ellis RJ, Jernigan TL, et al. Progressive cerebral volume loss in human immunodeficiency virus infection: a longitudinal volumetric magnetic resonance imaging study. Arch Neurol, 1998, 55(2): 161-168.
[30]
Ances BM, Ortega M, Vaida F, et al. Independent effects of HIV, aging, and HAART on brain volumetric measures. J Acquir Immune Defic Syndr, 2012, 59(5): 469-477.
[31]
Thompson PM, Dutton RA, Hayashi KM, et al. Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proc Natl Acad Sci U S A, 2005, 102(43): 15647-15652.
[32]
Cohen RA, Harezlak J, Schifitto G, et al. Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era. J Neurovirol, 2010, 16(1): 25-32.
[33]
Ragin AB, Du H, Ochs R, et al. Structural brain alterations can be detected early in HIV infection. Neurology, 2012, 79(24): 2328-2334.
[34]
Li Y, Li H, Gao Q, et al. Structural gray matter change early in male patients with HIV. Int J Clin Exp Med, 2014, 7(10): 3362-3369.
[35]
Zhou YW, Li RL, Wang XX, et al. Motor-related brain abnormalities in HIV-infected patients: a multimodal MRI study. Neuroradiology, 2017, 59(11): 1133-1142.
[36]
Pfefferbaum A, Rosenbloom MJ, Sassoon SA, et al. Regional brain structural dysmorphology in human immunodeficiency virus infection: effects of acquired immune deficiency syndrome, alcoholism, and age. Biol Psychiatry, 2012, 72(5): 361-370.
[37]
Ances BM, Hammoud DA. Neuroimaging of HIV-associated neurocognitive disorders (HAND). Curr Opin HIV AIDS, 2014, 9(6): 545-551.
[38]
Masters MC, Ances BM. Role of neuroimaging in HIV-associated neurocognitive disorders. Semin Neurol, 2014, 34(1): 89-102.
[39]
Valcour VG. HIV, aging, and cognition: emerging issues. Top Antivir Med, 2013, 21(3): 119-123.
[40]
Chang L, Speck O, Miller EN, et al. Neural correlates of attention and working memory deficits in HIV patients. Neurology, 2001, 57(6): 1001-1007.
[41]
Ances B, Vaida F, Ellis R, et al. Test-retest stability of calibrated BOLD- fMRI in HIV-and HIV+ subjects. Neuro Image, 2011, 54(3): 2156-2162.
[42]
Du Plessis S, Vink M, Joska J, et al. HIV infection and the fronto- striatal system: a systematic review and meta-analysis of fMRI studies. AIDS, 2014, 28(6): 803-811.
[43]
Ipser JC, Brown GG, Bischoff-Grethe A, et al. HIV infection is associated with attenuated frontostriatal intrinsic connectivity: a preliminary study. J Int Neuropsychol Soc, 2015, 21(3): 203-213.
[44]
Ann HW, Jun S, Shin NY, et al. Characteristics of resting-state functional connectivity in HIV-associated neurocognitive disorder. PLoS One, 2016, 11(4): e0153493.
[45]
Wang X, Foryt P, Ochs R, et al. Abnormalities in resting-state functional connectivity in early human immunodeficiency virus infection. Brain Connect, 2011, 1(3): 207-217.
[46]
Ortega M, Brier MR, Ances BM. Effects of HIV and combination antiretroviral therapy on cortico-striatal functional connectivity. AIDS, 2015, 29(6): 703-712.
[47]
Janssen MAM, Hinne M, Janssen RJ, et al. Resting-state subcortical functional connectivity in HIV-infected patients on long-term cART. Brain Imaging Behav, 2017, 11(5): 1555-1560.

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