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Value of DWI combined with MRS in glioma grade diagnosis
XIAO Guoqiang  WANG Shantao  XU Fenglin 

Cite this article as: Xiao GQ, Wang ST, Xu FL. Value of DWI combined with MRS in glioma grade diagnosis. Chin J Magn Reson Imaging, 2020, 11(7): 573-576. DOI:10.12015/issn.1674-8034.2020.07.019.


[Abstract] Objective: To analyze the value of diffusion weighted imaging (DWI) combined with hydrogen proton magnetic resonance spectroscopy (MRS) in glioma grade diagnosis.Materials and Methods: Between January 2017 and December 2018, 92 patients with glioma were selected as subjects, and grouped according to the results of DWI and MRS, of which 45 patients with grade Ⅰ to Ⅱ were classified into low-grade glioma group and 47 patients with grade Ⅲ to Ⅳ were classified into high-grade glioma group. All patients received DWI and MRS examinations. Various indexes were compared between groups, including apparent diffusion coefficient (ADC) value, N-acetylaspartate (NAA), creatine (Cr) and choline (Cho). The diagnostic value of DWI combined with MRS in different grades of gliomas was analyzed.Results: The ADC [(11.52±1.0)×10-3 mm2/s] and NAA/Cr in the low-grade group were significantly higher than those in the high-grade group ADC [(8.69±1.11)×10-3 mm2/s] and NAA/Cr (t=12.332, P<0.05; t=18.999, P<0.05). The Cho/Cr and Cho/NAA in the high-grade group were significantly higher than those in the low-garde group (t=34.164, P<0.05; t=40.962, P<0.05). Taking pathological diagnosis as gold standard, the sensitivity, specificity and accuracy of DWI examination were 77.78%, 76.60%, and 77.17%, respectively; the sensitivity, specificity and accuracy of MRS examination were 86.67%, 80.85%, and 83.70%; the sensitivity, specificity and accuracy of DWI combined with MRS were 93.33%, 95.74% and 94.57% (P<0.05). The diagnostic value of DWI and MRS was significantly lower than that of DWI combined with MRS (P<0.05).Conclusions: DWI combined with MRS parameters have certain clinical guiding value in glioma grade diagnosis with high sensitivity and specificity, which can provide some reference for clinical treatment and prognosis.
[Keywords] glioma；diffusion magnetic resonance imaging；magnetic resonance spectroscopy

XIAO Guoqiang* Department of Radiology, Xinjiang Cardiovascular and Cerebrovascular Disease Hospital, Urumqi 830011, China

WANG Shantao Department of Radiology, Xinjiang Cardiovascular and Cerebrovascular Disease Hospital, Urumqi 830011, China

XU Fenglin Department of Radiology, Xinjiang Cardiovascular and Cerebrovascular Disease Hospital, Urumqi 830011, China

*Corresponding to: XIAO GQ, E-mail: sbufbidcna@163.com

Conflicts of interest   None.

Received  2019-09-30
Accepted  2020-05-20
DOI: 10.12015/issn.1674-8034.2020.07.019
Cite this article as: Xiao GQ, Wang ST, Xu FL. Value of DWI combined with MRS in glioma grade diagnosis. Chin J Magn Reson Imaging, 2020, 11(7): 573-576. DOI:10.12015/issn.1674-8034.2020.07.019.

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