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• Clinical Article •
The value of amide proton transfer imaging in predicting the effect of nasopharyngeal carcinoma after chemoradiotherapy
YE Yufeng  XU Zongwei  ZENG Weihua  HUANG Bin  LUO Wenfeng  LIANG Jianke  ZOU Guorong  HUANG Bingsheng  CHEN Hanwei  LIU Dexiang 

Cite this article as: Ye YF, Xu ZW, Zeng WH, et al. The value of amide proton transfer imaging in predicting the effect of nasopharyngeal carcinoma after chemoradiotherapy. Chin J Magn Reson Imaging, 2020, 11(8): 635-640. DOI:10.12015/issn.1674-8034.2020.08.008.


[Abstract] Objective: To investigate the value of amide proton transfer (APT) imaging in predicting the efficacy of radiochemotherapy in nasopharyngeal carcinoma (NPC) during short and medium follow-up.Materials and Methods: The clinical information and MRI data of 40 NPC patients with radiochemotherapy were analyzed retrospectively. The patients were divided into two groups of recurrent group (n=14) and non-recurrence group (n=26). APT values were measured for each group. The rank sum test was used to compare the APT difference between the two groups before and during treatment. Receiver operator characteristic curve (ROC) was plotted to assess the diagnostic efficacy.Results: There was no significant difference in the mean, median and 90th percentile of APT between the recurrent and non-recurring groups before treatment. After 2 courses of chemotherapy and 5 courses of radiotherapy, although there was no significant difference of mean APT values between the two groups, the median and 90th percentile APT values were significantly different between the recurrent [(2.08±0.26)% and (4.45±0.86)% for median and 90th percentile values, respectively] and non-recurrence [(1.86±0.35)% and (3.64±0.70)% for median and 90th percentile values, respectively] groups (P<0.05). In addition, the optimum threshold, sensitivity, specificity, the area under the ROC curve (AUC), and 95% confidence interval of median and 90% digits are 1.80%, 85.7%, 65.4%, 0.753, 0.605—0.901 and 3.92%, 85.7%, 69.2%, 0.786, 0.627—0.945, respectively.Conclusions: The median of APT combined with 90th percentile can better predict the efficacy of radiochemotherapy for NPC.
[Keywords] nasopharyngeal carcinoma；magnetic resonance imaging；amide proton transfer；predictive effect

YE Yufeng Department of Radiology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China; Medical Imaging Institute of Panyu, Guangzhou 511400, China

XU Zongwei Paul C.Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

ZENG Weihua Department of Oncology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China

HUANG Bin School of Biomedical Engineering, Shenzhen University, Shenzhen 518000, China

LUO Wenfeng Medical Imaging Institute of Panyu, Guangzhou 511400, China

LIANG Jianke Department of Radiology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China; Medical Imaging Institute of Panyu, Guangzhou 511400, China

ZOU Guorong Paul C.Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

HUANG Bingsheng School of Biomedical Engineering, Shenzhen University, Shenzhen 518000, China

CHEN Hanwei Department of Radiology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China; Medical Imaging Institute of Panyu, Guangzhou 511400, China

LIU Dexiang* Department of Radiology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China; Medical Imaging Institute of Panyu, Guangzhou 511400, China

*Corresponding to: Liu DX, E-mail: liudexiang858@gmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Guangdong Science and Technology Project No. 2017ZC0374 Guangzhou Science and Technology Project No. 201804010111 Science and Technology Plan Project of Panyu District, Guangzhou No.2017-Z04-08
Received  2020-04-07
Accepted  2020-05-08
DOI: 10.12015/issn.1674-8034.2020.08.008
Cite this article as: Ye YF, Xu ZW, Zeng WH, et al. The value of amide proton transfer imaging in predicting the effect of nasopharyngeal carcinoma after chemoradiotherapy. Chin J Magn Reson Imaging, 2020, 11(8): 635-640. DOI:10.12015/issn.1674-8034.2020.08.008.

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