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• Clinical Article •
The relationship between the abnormal trigeminal root structure and the changes of local brain activity in classic trigeminal neuralgia patients
LIU Tianshui  LIU Meng  ZHOU Chun  WU Kaifu  TAN Yongming  HE Laichang 

Cite this article as: Liu TS, Liu M, Zhou C, et al. The relationship between the abnormal trigeminal root structure and the changes of local brain activity in classic trigeminal neuralgia patients. Chin J Magn Reson Imaging, 2020, 11(10): 848-852, 895. DOI:10.12015/issn.1674-8034.2020.10.003.


[Abstract] Objective: The changes of anisotropy fraction (FA), mean diffusion coefficient (MD), axial diffusion coefficient (AD), radial diffusion coefficient (RD) and amplitude of low-frequency fluctuation (ALFF) of trigeminal nerve root were collected by resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) to explore the changes of trigeminal nerve root structure and local brain activity relevance.Materials and Methods: Twenty five patients with unilateral classical trigeminal neuralgia (CTN) (CTN group) and 20 healthy controls (HCs matched by gender, age and education years recruited from the community at the same time) were scanned with resting fMRI and DTI. The values of FA, MD, AD, RD in trigeminal nerve root and ALFF in brain area between the two groups were tested with independent t-test. The brain ALFF and trigeminal rez of patients in CTN group were analyzed correlation between DTI parameters (FA, MD, AD, RD) and visual analogue score (VAS).Results: Compared with HCs group, ALFF values of bilateral cerebellum, bilateral fusiform gyrus, left inferior temporal gyrus, left inferior occipital gyrus, right superior occipital gyrus and right anterior central gyrus in CTN patients increased. Compared with HCs group, FA value of trigeminal nerve decreased (P<0.05), MD value increased (P<0.05), RD value increased (P<0.05), AD value was normal (P>0.05). There was a negative correlation between FA value and VAS score at rez of trigeminal nerve (r=-0.952, P<0.05), and a positive correlation between MD value and VAS score (r=0.848, P< 0.05). ALFF value of bilateral cerebellum, bilateral fusiform gyrus, left inferior temporal gyrus, left inferior occipital gyrus, right superior occipital gyrus and right anterior central gyrus was positively correlated with the score (P<0.05). FA value was negatively correlated with ALFF value of bilateral cerebellum, bilateral fusiform gyrus, left inferior temporal gyrus, left inferior occipital gyrus, right superior occipital gyrus and right anterior central gyrus (P<0.05).Conclusions: There is a correlation between the trigeminal nerve local structure damage and the brain functional change areas (pain processing, motor function and emotional perception) in CTN patients.
[Keywords] classical trigeminal neuralgia；functional magnetic resonance imaging；amplitude of low-frequency fluctuation；diffusion tensor imaging；pain；neuropathic pain

LIU Tianshui Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

LIU Meng Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

ZHOU Chun Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

WU Kaifu Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

TAN Yongming* Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

HE Laichang Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

*Correspondence to: Tan YM, E-mail:627871378@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81460329 Natural Science Foundation of Jiangxi Province No. 20192ACBL20039, 20181BAB205063
Received  2019-12-03
Accepted  2020-06-13
DOI: 10.12015/issn.1674-8034.2020.10.003
Cite this article as: Liu TS, Liu M, Zhou C, et al. The relationship between the abnormal trigeminal root structure and the changes of local brain activity in classic trigeminal neuralgia patients. Chin J Magn Reson Imaging, 2020, 11(10): 848-852, 895. DOI:10.12015/issn.1674-8034.2020.10.003.

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