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• CLINICAL ARTICLE •
Study on the correlation between body dysfunction and the degree of pyramidal tract injury in acute ischemic stroke by using diffusion tensor imaging technology
HAO Qing  DING Sixuan  LI Dongxue  LIU Huaijun  WANG Ning 

Cite this article as: Hao Q, Ding SX, Li DX, et al. Study on the correlation between body dysfunction and the degree of pyramidal tract injury in acute ischemic stroke by using diffusion tensor imaging technology[J]. Chin J Magn Reson Imaging, 2021, 12(1): 3-8, 20. DOI:10.12015/issn.1674-8034.2021.01.002.


[Abstract] Objective To study the correlation between body dysfunction and pyramidal tract injury in acute ischemic stroke by using diffusion tensor imaging technology.Materials and Methods Collect routine MRI scans, DWI, DTI examinations, fractional anisotropy maps (FA maps) and ADC maps generated from workstations automatically for patients with acute ischemic stroke during the acute phase of the disease. We selected 16 cases that the lesion just invade unilateral basal ganglia from acute ischemic stroke patients. Measure the FA values, ADC values, and fiber bundle numbers of the lesion area and the corresponding part of the opposite side of the brain, and calculate the difference between the healthy side and the affected side of the fiber bundle numbers. Use the Mimics software to measure the lesion volume, and use the national institutes of health stroke scale (NIH Stroke Scale, NIHSS), clinical medical muscle grading to evaluate the degree of functional impairment. Use statistical methods to study the differences in the number of fiber bundles, FA values, and ADC values on the affected side and the normal side; to calculate the correlation between the differences in fiber bundle numbers and the lesion volume, NIHSS score, and muscle strength score, to count all the positive manifestations of the nervous system in 16 patients. Diffusion tensor tractography (DTT) and 3D slicer software were used to reconstruct the fiber bundles of the lesions and the corresponding parts on the healthy side, and the morphological changes of the fiber bundles were compared and observed.Results There was a statistically significant difference between the number of pyramidal tracts, FA and ADC on the affected side and the same part on the normal side by using paired t test (P＜0.05,0.001,0.005,0.001, respectively ). There was a significant correlation between the difference in the number of fiber bundles and the lesion volume and muscle strength grade (r=0.632, P=0.009; r =-0.554, P=0.026), and there was a significant positive correlation between the lesion volume and NIHSS score (r=0.789, P=0.000). And the difference and correlation were statistically significant. There was no correlation between the difference in the number of healthy and affected side fiber bundles and NIHSS score (P=0.061), and there was no correlation between the degree of reduction in FA value and the degree of reduction in ADC volume (P=0.890). The shape of the affected fiber bundle was different from that of the healthy side. Some of the affected fiber bundles are compressed, deformed, displaced, and broken, and some of the fiber bundles on the normal side extend toward the affected side.Conclusions In patients with acute ischemic stroke, there was a correlation between body dysfunction and the degree of vertebral tract injury. The larger the lesion volume, the more severe the pyramidal tract injury was, the more severe the degree of brain tissue damage was, and the more obvious the body dysfunction was.
[Keywords] acute ischemic stroke；diffusion tensor imaging；pyramidal tract；dysfunction；magnetic resonance imaging

HAO Qing1   DING Sixuan1   LI Dongxue1   LIU Huaijun2*   WANG Ning2  

1 Second Clinical School of Medicine, Hebei Medical University, Hebei Province, Shijiazhuang 050000, China

2 Department of Imaging, the Second Hospital, Hebei Medical University, Shijiazhuang 050000, China

*Corresponding author: Liu HJ, E-mail: huaijunliu2@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Hebei Natural Science Found No. H2018206337
Received  2020-09-08
Accepted  2020-11-20
DOI: 10.12015/issn.1674-8034.2021.01.002
Cite this article as: Hao Q, Ding SX, Li DX, et al. Study on the correlation between body dysfunction and the degree of pyramidal tract injury in acute ischemic stroke by using diffusion tensor imaging technology[J]. Chin J Magn Reson Imaging, 2021, 12(1): 3-8, 20. DOI:10.12015/issn.1674-8034.2021.01.002.

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