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• CLINICAL ARTICLE •
Gender difference of gray and white matter surface area in major depressive disorder
MOU Jingping  CHENG Cai  MEI Lan  QIU Lihua  LONG Zhiliang  HU Xinyu  DIAO Xianming  CHEN Hongliang  GONG Qiyong 

Cite this article as: Mou JP, Cheng C, Mei L, et al. Gender difference of gray and white matter surface area in major depressive disorder[J]. Chin J Magn Reson Imaging, 2021, 12(1): 21-26, 37. DOI:10.12015/issn.1674-8034.2021.01.005.


[Abstract] Objective The purpose of present study was to explore the sex differences in gray and white matter surface area of major depressive disorder (MDD) patients and the relationship between these differences and clinical manifestations in different gender.Methods High resolution 3D T1WI data were collected of 61 MDD patients and 61 matched healthy controls (both groups were 25 males and 36 females) prospectively. FreeSurfer software was used to pre-process the 3D T1 data and obtained the gray and white matter surface area images of all brain regions. Two-factor ANCOVA model was used to analyze the differences of the surface area on gray and white matter among four groups and then post-hoc test was used to analyze the brain regions with differences between every two groups. Correlation analysis was used to analyze the gender differences regions of MDD and their clinical characterisitics.Result The main effect of sex difference in the surface area of gray and white matter was located in bilateral superior frontal gyrus, middle temporal gyrus, left rostral middle frontal gyrus, lateral occipital gyrus. In addition, the white matter surface area of bilateral superior temporal gyrus, left precentral gyrus, insular, right pars triangularis gyrus, medial orbitofrontal gyrus, fusiform gyrus, inferior parietal gyrus, and the gray matter surface area of left supramarginal gyrus, right rostral middle frontal gyrus, precentral gyrus, inferior temporal gyrus, fusiform gyrus, rostral anterior cingulate gyrus, lateral occipital gyrus and inferi orparietal lobule also exhibited gender differences (P＜0.01, Bonferroni correction). Post-hoc test showed that the surface area of the above brain regions in female MDD group was smaller than that in male MDD group (P＜0.01, Bonferroni correction). Correlation analysis found that the gray matter surface area of right rostralmiddlefrontal (r=-0.398，P=0.049) and fusiform gyrus (r=-0.440，P=0.028) were negatively correlated with the HAMD scores, and the gray matter surface area of left middle temporal gyrus was negatively correlated with the illness duration in male MDD patients (r=-0.419，P=0.037).Conclusions The current results showed gender effect on gray matter and white matter surface area between male and female MDD patients, but the brain regions do not completely overlap. These gender differences of surface area may be related to the different clinical manifestations and morbidity in male and female MDD patients.
[Keywords] depression；gender differences；magnetic resonance imaging；gray and white matter；surface area

MOU Jingping1   CHENG Cai2#   MEI Lan2   QIU Lihua1, 2*   LONG Zhiliang3   HU Xinyu4   DIAO Xianming2   CHEN Hongliang2   GONG Qiyong4  

1 Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 644000, China

2 Department of Radiology, the second people's hospital of yibin, Yibin 646000, China

3 Southwest University, Chongqing 400715, China

4 Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu 610041, China

#:Co first author：CHENG Cai

*Corresponding author: Qiu LH, E-mail: qiulihuah@gmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article was supported by Sichuan Science and Technology Program No. 2018JY0666 58th batches Chinese Postdoctoral Science Foundation No. 2015M582554 Sichuan Provincial Health and Family Planning Commission No. 150251 and Science and Technology Bureau of Yibin city No. 2015SF030
Received  2020-09-10
Accepted  2020-11-28
DOI: 10.12015/issn.1674-8034.2021.01.005
Cite this article as: Mou JP, Cheng C, Mei L, et al. Gender difference of gray and white matter surface area in major depressive disorder[J]. Chin J Magn Reson Imaging, 2021, 12(1): 21-26, 37. DOI:10.12015/issn.1674-8034.2021.01.005.

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