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• CLINICAL ARTICLE •
Probe of the central mechanism of analgesic effect of ozone water on patients with knee osteoarthritis pain based on rs-fMRI technique
TIAN Mingyue  CHEN Yunjie  DING Xiaofen  ZHANG Ruya  SONG Qiaoyan  HAN Songchen  ZHOU Youlong 

Cite this article as: Tian MY, Chen YJ, Ding XF, et al. Probe of the central mechanism of analgesic effect of ozone water on patients with knee osteoarthritis pain based on rs-fMRI technique[J]. Chin J Magn Reson Imaging, 2021, 12(1): 53-58. DOI:10.12015/issn.1674-8034.2021.01.011.


[Abstract] Objective To explore the central mechanism of analgesic effect of ozone water on knee osteoarthritis (KOA) patients with chronic pain by resting state functional magnetic resonance imaging (rs-fMRI), so as to provide theoretical basis for ozone water treatment of KOA.Materials and Methods Eighteen patients with KOA who met the inclusion criteria were treated with joint cavity irrigation with ozone water. Visual analogue score (VAS) and rs-fMRI scan were performed before and after ozone water treatment. Regional homogeneity (ReHo) t data analysis method was used to analyze the brain areas with significant changes in ReHo after ozone water treatment. Pearson correlation analysis was performed between the changed ReHo and the changed VAS score.Results After treatment with ozone water, ReHo values in different brain regions such as middle occipital gyrus, superior occipital gyrus, cuneiform lobe and angular gyrus in KOA patients increased, while ReHo values in superior temporal gyrus, central sulcus cover and precentral gyrus decreased. The results of correlation analysis showed that there was a negative correlation between the changes of ReHo and VAS in the right insular after ozone water treatment.Conclusions Ozone water therapy may treat pain in patients with KOA by regulating the function of temporal lobe, parietal lobe, frontal lobe and occipital lobe, while insular may be the critical brain area of ozone water analgesia.
[Keywords] ozone water；functional magnetic resonance imaging；local consistency；knee osteoarthritis；analgesia

TIAN Mingyue1   CHEN Yunjie1   DING Xiaofen1   ZHANG Ruya1   SONG Qiaoyan1   HAN Songchen1   ZHOU Youlong2*  

1 Colloge of Acupuncture and Massage, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China

2 Colloge of International Education, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China

*Corresponding author: Zhou YL, E-mail: youlong666@163.com

Conflicts of interest   None.

Received  2020-09-24
Accepted  2020-11-30
DOI: 10.12015/issn.1674-8034.2021.01.011
Cite this article as: Tian MY, Chen YJ, Ding XF, et al. Probe of the central mechanism of analgesic effect of ozone water on patients with knee osteoarthritis pain based on rs-fMRI technique[J]. Chin J Magn Reson Imaging, 2021, 12(1): 53-58. DOI:10.12015/issn.1674-8034.2021.01.011.

1
Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am, 2020, 104(2): 293-311. DOI: 10.1016/j.mcna.2019.10.007
2
Yi XJ, Zheng RG, Zhao M, et al. Meta analysis of the prevalence of knee osteoarthritis in middle-aged and elderly Chinese. Chin Tissue Engineer Res, 2012, 22(4): 650-656.
3
Sherwood J. Osteoarthritis year in review 2018: biology. Osteoarthritis Cartilage, 2019, 27(3): 365-370. DOI: 10.1016/j.joca.2018.10.005
4
Cheng S, Zhou J, Xu G, et al. Acupuncture and moxibustion for pain relief and quality of life improvement in patients with knee osteoarthritis: a protocol for systematic review and meta-analysis. Medicine (Baltimore), 2020, 99(22): e20171. DOI: 10.1097/MD.0000000000020171
5
Hosseini B, Taheri M, Ardekani RP, et al. Periarticular hypertonic dextrose vs intraarticular hyaluronic acid injections: a comparison of two minimally invasive techniques in the treatment of symptomatic knee osteoarthritis. Open Access Rheumatol, 2019, 11: 269-274. DOI: 10.2147/OARRR.S215576
6
Zhou YL, Hu CB, Zhang YQ, et al. Clinical observation of ozone-water joint cavity irrigation combined with point injection in the treatment of knee osteoarthritis. Chin Med Clin Res, 2008, 10(36): 69-71.
7
Vachon-Presseau E, Berger SE, Abdullah TB, et al. Identification of traits and functional connectivity-based neurotraits of chronic pain. PLoS Biol, 2019, 17(8): e3000349. DOI: 10.1371/journal.pbio.3000349
8
Lin X, Zhen D, Li H, et al. Altered local connectivity in chronic pain: a voxel-wise meta-analysis of resting-state functional magnetic resonance imaging studies. Medicine (Baltimore), 2020, 99(31): e21378. DOI: 10.1097/MD.0000000000021378
9
Ihara N, Wakaizumi K, Nishimura D, et al. Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients. PLoS One, 2019, 14(8): e0221023. DOI: 10.1371/journal.pone.0221023
10
Seretny M, Murray SR, Whitaker L, et al. The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study. BMJ Open, 2019, 9(6): e026152. DOI: 10.1136/bmjopen-2018-026152
11
Fang KW, Wang YR, Zhang Let al. Study on local consistency of resting cerebral functional magnetic resonance in patients with cervical headache. Chin J Pain Med, 2020, 26(5): 350-356.
12
Cottam WJ, Iwabuchi SJ, Drabek MM, et al. Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. Pain, 2018, 159(5): 929-938. DOI: 10.1097/j.pain.0000000000001209
13
Xiao Y, Liu J, Hu K, et al. FMRI study of the functional connectivity characteristics of nucleus accumbens in patients with knee osteoarthritis. J Rehabilitat, 2020, 30(1): 40-45.
14
Liao X, Mao C, Wang Y, et al. Brain gray matter alterations in Chinese patients with chronic knee osteoarthritis pain based on voxel-based morphometry. Med (Baltimore), 2018, 97(12): e0145. DOI: 10.1097/MD.0000000000010145
15
Pujol J, Martínez-Vilavella G, Llorente-Onaindia J, et al. Brain imaging of pain sensitization in patients with knee osteoarthritis. Pain, 2017, 158(9): 1831-1838. DOI: 10.1097/j.pain.0000000000000985
16
Soni A, Wanigasekera V, Mezue M, et al. Central sensitization in knee osteoarthritis: relating presurgical brainstem neuroimaging and pain DETECT-based patient stratification to arthroplasty outcome. Arthritis Rheumatol, 2019, 71(4): 550-560. DOI: 10.1002/art.40749
17
Guo J, Chen Y, Li Z, et al. The cerebral mechanism of acupuncture for treating knee osteoarthritis: study protocol for a randomized controlled trial. Trials, 2019, 20(1): 126. DOI: 10.1186/s13063-019-3233-7
18
Tang C, Dong X, He W, et al. Cerebral mechanism of celecoxib for treating knee pain: study protocol for a randomized controlled parallel trial. Trials, 2019, 20(1): 58. DOI: 10.1186/s13063-018-3111-8
19
Yue Y, Collaku A. Correlation of pain reduction with fMRI BOLD response in osteoarthritis patients treated with paracetamol: randomized, double-blind, crossover clinical efficacy study. Pain Med, 2018, 19(2): 355-367. DOI: 10.1093/pm/pnx157
20
Liu J, Chen L, Tu Y, et al. Different exercise modalities relieve pain syndrome in patients with knee osteoarthritis and modulate the dorsolateral prefrontal cortex: a multiple mode MRI study. Brain Behav Immun, 2019, 82: 253-263. DOI: 10.1016/j.bbi.2019.08.193
21
Li LG, Yu Z, Xu BB, et al. Effect of massage combined with ozone water joint cavity flushing on joint function in 80 patients with knee osteoarthritis. Chin J Prevent Med, 2019, 37(8): 152-154.
22
Li XY, Chen XL, Wei CF, et al. Clinical study of medical ozone gas intra-articular injection combined with medical ozone water pain point injection in the treatment of knee osteoarthritis. J Gannan Med College, 2019, 39(7): 668-671.
23
Hei G, Li JF, Zhang J, et al. Clinical efficacy of ozone water in the treatment of knee osteoarthritis and its influence on articular fluid cytokines. Chin J Pain Med, 202, 26(2): 150-152.
24
Shi AJ, Li CL, Wu Y, et al. Study on local consistency of brain function in patients with knee osteoarthritis with chronic pain resting state. J Local Surg Sci, 2017, 26(6): 419-422.
25
Kobayashi M. Macroscopic connection of rat insular cortex: anatomical bases underlying its physiological functions. Int Rev Neurobiol, 2011, 97(97): 285. DOI: 10.1016/B978-0-12-385198-7.00011-4

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