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• EXPERIENCE EXCHANGES •
The guiding significance of parameter optimized MRI on thrombolytic therapy in patients with ischemic stroke
ZHU Hong  ZHANG Jing  HUANG Baosheng  WANG Yingchao  YAN Lihong 

Cite this article as: Zhu H, Zhang J, Huang BS, et al. The guiding significance of parameter optimized MRI on thrombolytic therapy in patients wit hischemic stroke[J]. Chin J Magn Reson Imaging, 2021, 12(2): 67-69, 78. DOI:10.12015/issn.1674-8034.2021.02.015.


[Abstract] Objective To explore the efficacy and clinical significance of parametric optimal MRI in the thrombolytic therapy of acute ischemic stroke (AIS). Materials andMethods Control study was used. All the 112 cases of AIS patients admitted to the department of neurology of Zhangye People's Hospital Affiliated to Hexi University from March 2018 to March 2020 were selected as the research objects. Among them, 54 cases of AIS patients admitted from March 2018 to February 2019 were included in the control group, and 58 cases of AIS patients admitted from March 2019 to March 2020 were included in the study group. The head MRI was the preferred imaging examination, and intravenous thrombolysis was performed in the control group, conventional MRI examination was performed in the control group, and parameter optimization MRI examination was performed in the research group. The two groups were compared in terms of the time from admission to MRI (DIT), MRI to imaging to needle time (INT), MRI examination time, and onset to needle time(ONT), door-to-needle time (DNT), and the rate of MRI examination before treatment, DNT＜60 min ratio, mRS score 0—2 at discharge, and the occurrence of symptomatic cerebral hemorrhage and death.Results In the study group, ONT, INT, MRI examination time, DIT and DNT were (178.56±39.20) min, (30.15±5.24) min, (5.30±0.42) min, (26.91±5.72) min, (58.31±10.47) min, respectively. The control group was (204.13±35.29) min, (43.48±12.80) min, (10.08±1.04) min, (49.04±12.55) min, and (87.20±23.92) min, respectively, with statistically significant differences (P＜0.05). Before treatment, 81.03% of the study group received MRI examination, DNT＜60 min accounted for 67.24%, and mRS score of 0—2 accounted for 60.34% at discharge, while the control group was 61.11%, 14.81%, and 44.44%, respectively. The difference was statistically significant (P＜0.05). However, there was no significant difference between symptomatic cerebral hemorrhage rate (1.72% VS 3.52%) and mortality rate (1.72% VS 3.52%) (P＞0.05).Conclusions Optimization of MRI can provide good guidance for thrombolytic therapy of AIS patients within 4.5 h, effectively shorten the time from admission to thrombolytic therapy, and improve the efficiency of clinical treatment. Therefore, MRI can be used as the preferred examination method.
[Keywords] magnetic resonance imaging；stroke；thrombolytic therapy；guidelines

ZHU Hong1   ZHANG Jing2*   HUANG Baosheng1   WANG Yingchao1   YAN Lihong1  

1 Department of Imaging Diagnosis, Zhangye People's Hospital Affiliated to Hexi University, Zhangye 734000, China

2 Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China

Zhang J, E-mail: lztong2001@163.com

Conflicts of interest   None.

ACKNOWLEDGENTS This work was part of Innovation Fund Project of Gansu Education Department (No.2020A-107); The Key Project of the Principal Fund Forof Scientific Research Innovation and Application of Hexi University (No.XZZD2018001).
Received  2020-09-26
Accepted  2021-01-11
DOI: 10.12015/issn.1674-8034.2021.02.015
Cite this article as: Zhu H, Zhang J, Huang BS, et al. The guiding significance of parameter optimized MRI on thrombolytic therapy in patients wit hischemic stroke[J]. Chin J Magn Reson Imaging, 2021, 12(2): 67-69, 78. DOI:10.12015/issn.1674-8034.2021.02.015.

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