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• Technical Article •
The value of diffusion-weighted imaging of single index, double index and stretch index models in the differential diagnosis of orbital benign and malignant tumors
WANG Shang  BAI Yan  WANG Meiyun  CHEN Chuanliang 

Cite this article as: Wang S, Bai Y, Wang MY, et al. The value of diffusion-weighted imaging of single index, double index and stretch index models in the differential diagnosis of orbital benign and malignant tumors[J]. Chin J Magn Reson Imaging, 2021, 12(3): 44-48. DOI:10.12015/issn.1674-8034.2021.03.010.


[Abstract] Objective To explore the value of single index, double index and stretch index model DWI in the differentiation of orbital benign and malignant tumors. Materials andMethods Fifty-one patients with orbital tumors confirmed by surgery and pathology from January 2019 to December 2019 were enrolled. They underwent 3.0 T conventional magnetic resonance and multi-b value DWI examination before surgery. Among them, 26 were benign and 25 were malignant. Use GE ADW4.6 Functiontool post-processing software to measure the apparent diffusion coefficient (ADC) value of the single exponential model, the slow apparent diffusion coefficient (ADCslow) value, the fast apparent diffusion coefficient (ADCfast), perfusion fraction (f) value of the double exponential model, and the distributed diffusion coefficient (DDC) value、the heterogeneity of intravoxel diffusion (α) value of stretch index model, compare the difference of each parameter value. Receiver operating characteristic curve (ROC) was used to evaluate the effectiveness of statistically different parameters in the differential diagnosis of orbital benign and malignant.Results ADC, ADCslow, DDC and α values were significantly different in the differential diagnosis of benign tumors and malignant tumors (P＜0.05). Among them, the area under the receiver operating characteristic curve of DDC and ADCslow was the largest, respectively 0.84 and 0.81, the diagnostic threshold was 1.15×10－3 mm2/s (sensitivity, 79.20%; specificity, 92.60%) and 0.60×10－3 mm2/s (sensitivity 87.50%; specificity 66.70%).Conclusions Diffusion weighted imaging with double index and stretch index models provides more information for the differential diagnosis of orbital tumors from benign and malignant. Compared with the ADC value generated by traditional single index DWI, ADCslow and DDC have greater advantages in the differential diagnosis of benign and malignant orbital tumors. The combination of ADCslow, DDC, and α has the highest diagnostic efficiency.
[Keywords] orbital tumors；magnetic resonance imaging；diffusion weighted imaging；differential diagnosis；single index；double index；stretch index

WANG Shang   BAI Yan   WANG Meiyun   CHEN Chuanliang*  

Department of Medical Imaging, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, China

Chen CL, E-mail: henanccl@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Supported by the National Key Research and Development Program of China No. 2017YFE0103600 National Natural Science Foundation of China No. 81601466
Received  2020-09-03
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.03.010
Cite this article as: Wang S, Bai Y, Wang MY, et al. The value of diffusion-weighted imaging of single index, double index and stretch index models in the differential diagnosis of orbital benign and malignant tumors[J]. Chin J Magn Reson Imaging, 2021, 12(3): 44-48. DOI:10.12015/issn.1674-8034.2021.03.010.

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