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• Clinical Article •
Correlation analysis of 3.0 T magnetic resonance spectroscopy combined with diffusion tensor imaging in children with medulloblastoma
ZHU Kai  ZENG Lihong  ZHANG Xiaofan  XU Shoucheng  HAO Mingzhu  CAI Jingyi 

Cite this article as: Zhu K, Zeng LH, Zhang XF, et al. Correlation analysis of 3.0 T magnetic resonance spectroscopy combined with diffusion tensor imaging in children with medulloblastoma[J]. Chin J Magn Reson Imaging, 2021, 12(5): 12-15, 54. DOI:10.12015/issn.1674-8034.2021.05.003.


[Abstract] Objective To investigate the value of 1H-magnetic resonance spectroscopy (MRS) combined with diffusion tensor imaging (DTI) in the treatment of medulloblastoma (MB) in children. Materials andMethods Twenty-one patients with MB confirmed by pathology were examined by 1H-MRS and DTI. The changes of metabolite information, ADC, FA and DTT were observed. The differences of N-acetylaspartic acid (NAA), creatine (Cr), choline (Cho), NAA/Cr, Cho/Cr, Cho/NAA, apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in tumor center, tumor periphery and normal tissues were analyzed.Results In 21 cases of MB, the tumors occurred in the vermis (11/21), the fourth ventricle (7/21) and the right cerebellar hemisphere (3/21), male/female (13/8), the average age of onset was (28.20±22.24) months in male, (37.37±21.86) months in female, (75.30±52.42) cm3 in male and (86.72±49.41) cm3 in female. MRS showed that the peak Cho wave increased, the peak of NAA decreased, the peak of NAA/Cr decreased, the peak of Cho/Cr increased; in DTI data, the ADC value of tumor center was low, the FA value was high, DTT showed that the fiber bundle was fine and disordered, and the local continuity of the fiber bundle in the tumor area was interrupted and pushed.Conclusions 1H-MRS and DTI are consistent in MB display, and different principles give consistent results. At different cell and molecular levels, they can provide more accurate lesion range and help for operation.
[Keywords] children；medulloblastoma；hydrogen proton spectroscopy；diffusion tensor imaging；correlation analysis

ZHU Kai*   ZENG Lihong   ZHANG Xiaofan   XU Shoucheng   HAO Mingzhu   CAI Jingyi  

Imaging department of Harbin Children's Hospital, Harbin 150010, China

Zhu K, E-mail: 2008mr-zhukai@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was part of Seed Fund of Harbin Children's Hospital (No. HEY201606).
Received  2020-12-18
Accepted  2021-03-25
DOI: 10.12015/issn.1674-8034.2021.05.003
Cite this article as: Zhu K, Zeng LH, Zhang XF, et al. Correlation analysis of 3.0 T magnetic resonance spectroscopy combined with diffusion tensor imaging in children with medulloblastoma[J]. Chin J Magn Reson Imaging, 2021, 12(5): 12-15, 54. DOI:10.12015/issn.1674-8034.2021.05.003.

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