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• Clinical Article •
The study of white matter micro-structures mediating onset age and the severity of depressive disorder based on DTI
WANG Yun  ZHAO Tian  XIE Jie  WANG Qi  LI Yuefeng 

Cite this article as: Wang Y, Zhao T, Xie J, et al. The study of white matter micro-structures mediating onset age and the severity of depressive disorder based on DTI[J]. Chin J Magn Reson Imaging, 2021, 12(6): 1-4, 15. DOI:10.12015/issn.1674-8034.2021.06.001.


[Abstract] Objective To investigate the relationship among onset age, white matter (WM) micro-structures and the severity of depressive disorder and explore the effect of WM micro-structures on the association between onset age and the severity of depressive disorder. Materials andMethods Prospective design was used in this study. Sixty depressive disorder patients (26 early-onset and 34 later-onset depressive disorder groups) collected from Zhenjiang Mental Health Center underwent DTI-MRI scanning, and analysis was performed using the tract-based spatial statistics (TBSS). The severity of depressive disorder was assessed by Hamilton Depression Rating Scale (HAMD). The WM micro-structures between the early-onset and the later-onset depressive disorder groups were compared with two-sample t-test and generalized linear models. The correlation among onset age, abnormal WM micro-structures and the severity of depressive disorder were analyzed by Pearson correlation. The mediation effect models were used to explore the influence of abnormal WM micro-structures in the potential association between onset age and the severity of depressive disorder.Results The onset age was positively correlated with the severity of depressive disorder in the early-onset and later-onset depressive disorder groups (r=0.512, P=0.007; r=0.435, P=0.010). Compared with the early-onset depressive disorder group, FA values of the left internal capsule and right sagittal stratum including inferior fronto-occipital fasciculus and inferior longitidinal fasciculus significantly decreased in later-onset depressive disorder group (P＜0.05). The differences remained statistically significant (P＜0.05), even after controlling for covariates. Pearson correlation analysis showed that the FA values of the left internal capsule and right sagittal stratum including inferior fronto-occipital fasciculus and inferior longitidinal fasciculus were respectively significantly negatively correlated with onset age and HAMD scores (r=-0.434, P=0.001; r=-0.594, P=0.001; r=-0.565, P=0.001, r=-0.370, P=0.004) after controlling for covariates. The mediation effect model showed that FA values of the left internal capsule had a significant mediation effect on the association between onset age and the severity of depressive disorder (ab path=0.155, SE=0.055, 95% CI: 0.059—0.276).Conclusions FA values of the left internal capsule mediated the influence of onset age on the severity of depressive disorder.
[Keywords] depressive disorder；onset age；white matter micro-structures；the severity of depressive disorder；diffusion tensor imaging

WANG Yun   ZHAO Tian   XIE Jie   WANG Qi   LI Yuefeng*  

Department of Radiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China

Li YF, E-mail: jiangdalyf123@163.com

Conflicts of interest   None.

This work was part of National Natural Science Foundation of China (No. 81871343) and Jiangsu Provincial Key Research and Development Plan (No. BE2017698).
Received  2021-01-19
Accepted  2021-03-08
DOI: 10.12015/issn.1674-8034.2021.06.001
Cite this article as: Wang Y, Zhao T, Xie J, et al. The study of white matter micro-structures mediating onset age and the severity of depressive disorder based on DTI[J]. Chin J Magn Reson Imaging, 2021, 12(6): 1-4, 15. DOI:10.12015/issn.1674-8034.2021.06.001.

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