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• Original Article •
Changes of positive and negative network connectivity related to hand knob area after stroke: A rs-fMRI study
ZHAN Shuang  YU Qiurong  YIN Dazhi  WANG Hewei  XU Guojun  WANG Xuefei  GUO Miao  SUN Changhui  ZHU Bing  SUN Limin  FAN Mingxia 

Cite this article as: Zhang S, Yu QR, Yin DZ, et al. Changes of positive and negative network connectivity related to hand knob area after stroke: A rs-fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(6): 44-50. DOI:10.12015/issn.1674-8034.2021.06.009.


[Abstract] Objective To explore the changes of positive and negative network connectivity related to hand knob area and their correlation with motor dysfunction after subcortical stroke. Materials andMethods Eighteen unilateral subcortical stroke patients and 18 healthy volunteers with matched gender and age were examined by resting state functional magnetic resonance imaging (rs-fMRI). The primary motor cotex (M1, corresponding to the lesion side) related to hand knob area was selected as the region of interest (ROI), and the positive and negative network based on the voxel-wise whole brain functional connectivity method were analyzed; the intra-network and inter-network of the two networks based on the ROI-wise functional connectivity method were also analyzed. Finally, the abnormal functional connectivity index were correlated with the upper limb motor scores in stroke patients.Results Compared with healthy controls (HCs), some brain regions with significantly greater FC with the M1 in the stroke group were all within the negative network; while other brain regions with significantly lower FC with the M1 were all within the positive functional network;. and the intra-network and inter-network FC strength of the two networks were significantly decreased. In addition, the FC coefficient of the ipsilesional middle frontal gyrus were negatively correlated with the patient's upper limb motor function scores (r=-0.735, P＜0.01).Conclusions The positive and negative network connectivity strength related to hand knob area both decrease following subcortical stroke. In particular, the FC in the stroke group greater than that in the control group does not mean "functional compensation", but reflects the degradation FC in the brain regions related to hand knob area. It may be helpful for our deep understanding of the neuropathyological mechanism of stroke and provide reference for rehabilitation intervention.
[Keywords] magnetic resonance imaging；stroke；primary motor cortex；functional connectivity；resting-state network

ZHAN Shuang1   YU Qiurong1   YIN Dazhi2   WANG Hewei3   XU Guojun1   WANG Xuefei1   GUO Miao1   SUN Changhui3   ZHU Bing3   SUN Limin3*   FAN Mingxia1*  

1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

2 School of Psychology and Cognitive science, East China Normal University, Shanghai 200062, China

3 Huashan Hospital, Fudan University, Shanghai 200040, China

Fan MX, E-mail: mxfan@phy.ecnu.edu.cn Sun LM, E-mail: tracy611@sina.com

Conflicts of interest   None.

This work was part of National Natural Science Foundation of China (No. 81471651, 81974356); Young National Natural Science Foundation of China (No. 81401859); National Key R&D Program of China (No. 2020YFC2004200).
Received  2021-03-26
Accepted  2021-05-08
DOI: 10.12015/issn.1674-8034.2021.06.009
Cite this article as: Zhang S, Yu QR, Yin DZ, et al. Changes of positive and negative network connectivity related to hand knob area after stroke: A rs-fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(6): 44-50. DOI:10.12015/issn.1674-8034.2021.06.009.

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