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• Clinical Article •
Study of brain magnetic resonance imaging in patients with hypertension and type 2 diabetes mellitus based on DKI technology
YANG Jiehua  YANG Zhongxian  CHEN Chunjuan  WU Huanze  CHEN Wei  ZHU Zhihong 

Cite this article as: Yang JH, Yang ZX, Chen CJ, et al. Study of brain magnetic resonance imaging in patients with hypertension and type 2 diabetes mellitus based on DKI technology[J]. Chin J Magn Reson Imaging, 2021,12(7): 1-5, 17. DOI:10.12015/issn.1674-8034.2021.07.001.


[Abstract] Objective To evaluate the early subclinical brain cell damage in patients with hypertension and type 2 diabetes mellitus (T2DM) by diffusion kurtosis imaging (DKI). Materials andMethods Twenty-six patients with hypertension and T2DM without neurological function and cognitive impairment, 27 patients with simple hypertension and 16 healthy subjects matched with gender, age and education level, were enrolled in this study, brain MRI and DKI were performed in three groups.The mean kurtosis (MK), mean diffusivity (MD) and fractional anisotropy (FA) of bilateral hippocampal gyrus, centrum semiovale, caudate head, posterior limb of internal capsule, thalamus, red nucleus, substantia nigra, pons and cerebellum were measured.Results There were significant differences in MK values of left hippocampus gyrus, left centrum semiovale, bilateral caudate head and left posterior limb of internal capsule between three groups (P＜0.05 or P＜0.01), and there were significant differences in MK values of bilateral thalamus and left substantia nigra between some groups (P＜0.05 or P＜0.01). MD value in the right thalamus was significantly different between the three groups (P＜0.05 or P＜0.01), MD value in the right caudate head was significantly different between the some groups (P＜0.05 or P＜0.01). There was significant difference in FA value of left posterior limb of internal capsule between the three groups (P＜0.05 or P＜0.01), and there were significant difference in FA values of left centrum semiovale, right posterior limb of internal capsule between the some groups (P＜0.05 or P＜0.01).Conclusions The brain cell of hippocampus gyrus, centrum semiovale, caudate head, posterior limb of internal capsule, thalamus and substantia nigra has been damaged in patients with hypertension and T2DM, and the damage was more serious than that in patients with simple hypertension.
[Keywords] hypertension with type 2 diabetes mellitus；essential hypertension；magnetic resonance imaging；diffusion kurtosis imaging；subclinical brain cell damage

YANG Jiehua1   YANG Zhongxian2   CHEN Chunjuan3   WU Huanze1   CHEN Wei1   ZHU Zhihong4*  

1 Department of Neurology, the Second Affiliated Hospital, Medical Academy of Shantou University, Shantou 515041, China

2 Department of Medical Imaging Center, Shenzhen Hospital of Southern Medical University, Shenzhen, 518000, China

3 Department of Cardiology, the Second Affiliated Hospital, Medical Academy of Shantou University, Shantou 515041, China

4 Department of Endocrinology, the Second Affiliated Hospital, Medical Academy of Shantou University, Shantou 515041, China

Zhu ZH, 56346301@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This article is supported by the Guangdong Medical Science and Technology Research Fund (No. A2019278).
Received  2021-03-22
Accepted  2021-04-20
DOI: 10.12015/issn.1674-8034.2021.07.001
Cite this article as: Yang JH, Yang ZX, Chen CJ, et al. Study of brain magnetic resonance imaging in patients with hypertension and type 2 diabetes mellitus based on DKI technology[J]. Chin J Magn Reson Imaging, 2021,12(7): 1-5, 17. DOI:10.12015/issn.1674-8034.2021.07.001.

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