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• Clinical Article •
Semiquantitative and quantitative analyses of dynamic contrast-enhanced magnetic resonance imaging in the differentiation between malignant and benign thyroid nodules
HE Pin  Huerman•Bahetibieke   ZHANG Miaoru  LIU Zhou  WANG Shixu  LIANG Longfei  LONG Li  DENG Wenming  WEI Minghui  LUO Dehong 

Cite this article as: He P, Huerman•Bahetibieke, Zhang MR, et al. Semiquantitative and quantitative analyses of dynamic contrast-enhanced magnetic resonance imaging in the differentiation between malignant and benign thyroid nodules[J]. Chin J Magn Reson Imaging, 2021, 12(7): 12-17. DOI:10.12015/issn.1674-8034.2021.07.003.


[Abstract] Objective To investigate the diagnostic efficacy of semiquantitative and quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters in the differentiation of malignant and benign of thyroid nodules. Materials andMethods In this retrospective analysis, 45 patients with pathological confirmed thyroid nodule and presurgical DCE-MRI were enrolled. For each lesion, quantitative MRI kinetics including: volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular volume fraction (Ve) and semiquantitative MRI kinetic including: initial area under gadolinium concentration time curve (IAUGC), maximum slope of increase (Max Slope), contrast enhancement rate (CER), time-intensity curves (TIC) were plotted and calculated obtained. The Mann-Whitney U test and Fisher exact test was used to test the statistically significant differences of in continuous and categorical parameters between benign and malignant nodules, respectively. Then, ROC curve analysis was performed to assess the diagnostic efficiency of each parameter in differentiating benign and malignant nodule.Results Among 45 patients, 12 benign and 34 malignant lesions were identified. No significant differences were found between malignant and benign lesions in mean Ktrans, Ve, and Kep for benign lesions were (3.63±2.83) min-1 vs. (2.70±2.42) min-1, (1.41±1.01) min-1 vs. (1.23±1.23) min-1, (0.48±0.19) min-1 vs. (0.51±0.22) min-1 respectively (all P＞0.05). However, for semiquantitative parameters, significant difference was found in CER (benign vs malignant =[(2.04±0.67) seconds vs. (1.55±0.67) seconds, P=0.04], but not in Max Slope [(0.10±0.10) seconds vs. (0.07±0.10) seconds, P=0.37] and IAUGC [(0.78±0.38) seconds vs. (0.94±0.67) seconds, P=0.45]. The optimal specificity and sensitivity for the CER were 0.75, 0.62 respectively with AUC of 0.72 most of the masses with type-Ⅱcurve were malignant (16/31) and type-Ⅲ curve were benign (10/12) with significant difference (P=0.02).Conclusions DCE-MRI, especially the semi-qualitative TIC pattern and quantitative value of CER could be potential indicators in distinguishing malignant benign and malignant thyroid lesions. However, no significant value was shown using DCE-MRI-based quantitative parameters to differentiate benign and malignant thyroid nodules, which warrants further investigation with larger sample size data.
[Keywords] thyroid nodules；dynamic contrast enhancement magnetic resonance imaging；semiquantitative analysis；quantitative analysis；time intensity curve

HE Pin1#   Huerman•Bahetibieke 2#   ZHANG Miaoru1   LIU Zhou1   WANG Shixu2   LIANG Longfei2   LONG Li1   DENG Wenming1   WEI Minghui2*   LUO Dehong1, 3*  

1 National Cancer Center/National Clinical Research Center for Cancer, Department of Radiology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518000, China

2 National Cancer Center, National Clinical Research Center for Cancer, Department of Head and Neck Surgery, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518000, China

3 National Cancer Center, National Clinical Research Center for Cancer, Department of Radiology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Luo DH, E-mail: cjr.luodehong@vip.163.com Wei MH, E-mail: Minghuiwei@163.com;

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was supported in part by the Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Projects (No. SZ2020ZD005).
Received  2021-02-25
Accepted  2021-04-19
DOI: 10.12015/issn.1674-8034.2021.07.003
Cite this article as: He P, Huerman•Bahetibieke, Zhang MR, et al. Semiquantitative and quantitative analyses of dynamic contrast-enhanced magnetic resonance imaging in the differentiation between malignant and benign thyroid nodules[J]. Chin J Magn Reson Imaging, 2021, 12(7): 12-17. DOI:10.12015/issn.1674-8034.2021.07.003.

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