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• Clinical Article •
Correlation between 1H-MRS of frontal lobe white matter and cognitive function in mild cognitive impairment
TAN Zhilin  XIE Qi  LIAO Yanhui  WANG Yajie  DU Lei  CHEN Huixian 

Cite this article as: Tan ZL, Xie Q, Liao YH, et al. Correlation between 1H-MRS of frontal lobe white matter and cognitive function in mild cognitive impairment[J]. Chin J Magn Reson Imaging, 2021, 12(8): 6-10. DOI:10.12015/issn.1674-8034.2021.08.002.


[Abstract] Objective To investigate the patterns of metabolic changes in frontal white matter and its diagnostic value for mild cognitive impairment (MCI). Materials andMethods Neuropsychological tests were prospectively performed to evaluate 174 volunteers recruited from the community, and they were seperated into two groups: MCI and normal control (NC). At the same time, single-voxel 1H-MRS sequence was performed on bilateral frontal white matter. LCModel was conducted for calculating the relative concentration of metabolites automatically. Covariance analysis, independent-samples t test and nonparametric Mann-Whitney U test were used to compare the inter-group differences of relative concentration of metabolites. Pearson and Spearman correlation analysis methods were performed to explore the correlation between the relative concentration of metabolites and neuropsychological test scores.Results Elderly subjects of MCI group (≥ 60 years old) had higher relative concentration of glutamate and glutamine in the left frontal white matter than elderly normal controls (1.77±0.08, 1.48±0.08; Z=2.640, P＜0.05). the performance of auditory verbal learning test(AVLT) delay recalled and recognition was negatively correlated with relative concentration of N-acetylaspartate and N-acetylaspartylglutamate (NAA+NAAG) of right frontal white matter in MCI group (r=-0.241, -0.342, all P＜0.05); the completion time of shape trails test (STT)-A was positively correlated with relative concentration of N-acetylaspartate and N-acetylaspartylglutamate(NAA+NAAG) of left frontal white matter (r=-0.235, P=0.044); the completion time of STT-A and STT-B tests were of positive correlation with inositol of right frontal white matter (r=0.379, 0.398, all P＜0.05).Conclusions Metabolites changes detected by 1H-MRS may be expected as a clinical reference for early diagnosis of MCI.
[Keywords] magnetic resonance spectroscopy；mild cognitive impairment；neuropsychological examination；frontal lobe；cerebral metabolites

TAN Zhilin1   XIE Qi1*   LIAO Yanhui2   WANG Yajie1   DU Lei2   CHEN Huixian3  

1 School of Medicine, South China University of Technology, Guangzhou 510006, China

2 Department of Imaging, Nansha Hospital, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China

3 Department of Imaging, Nansha Hospital, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou 510180, China

Xie Q, E-mail: eyqixie@scut.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was part of Guangzhou Science and Technology Plan Project (No. 201907010020).
Received  2021-03-26
Accepted  2021-05-24
DOI: 10.12015/issn.1674-8034.2021.08.002
Cite this article as: Tan ZL, Xie Q, Liao YH, et al. Correlation between 1H-MRS of frontal lobe white matter and cognitive function in mild cognitive impairment[J]. Chin J Magn Reson Imaging, 2021, 12(8): 6-10. DOI:10.12015/issn.1674-8034.2021.08.002.

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