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• Clinical Article •
Preliminary study of quantitative susceptibility mapping in the brain iron deposition of unilateral middle cerebral artery stenosis or occlusion
MAO Huimin  WANG Xinyi  CHEN Kunjian  GUO Yu  WANG Xinyu 

Cite this article as: Mao HM, Wang XY, Chen KJ, et al. Preliminary study of quantitative susceptibility mapping in the brain iron deposition of unilateral middle cerebral artery stenosis or occlusion[J]. Chin J Magn Reson Imaging, 2021, 12(11): 16-20. DOI:10.12015/issn.1674-8034.2021.11.004.


[Abstract] Objective The MR quantitative susceptibility mapping (QSM) was used to explore the iron deposition of brain gray matter nucleus in patients with unilateral middle cerebral artery (MCA) stenosis or occlusion.Materials and Methods: Thirty-three patients with unilateral MCA stenosis or occlusion underwent QSM and conventional MRI scan by GE 3.0 T MR. After processing the original images, QSM images were obtained. Susceptibility values of bilateral caudate nucleus, putamen, globus pallidus and thalamus were measured and compared between the lesion side and the contralateral side by paired sample t-test. According to the degree of lumen stenosis, the 33 patients were divided into mild and moderate stenosis group, severe stenosis group and occlusion group. One-way analysis of variance was used to compare the differences of susceptibility values of gray matter nucleus in the three groups.Results There was significant difference in susceptibility values of caudate nucleus, putamen and globus pallidus between the lesion side and the contralateral side in 33 subjects (P＜0.05), while there was no significant difference in susceptibility values of thalamus on both sides (P＞0.05). And there was no statistical significance among the above three groups (P＞0.05).Conclusions The QSM technique found that the iron content in gray matter nucleus of the lesion side in patients with unilateral MCA stenosis or occlusion was higher than the contralateral side, which further deepens the understanding of the pathophysiological changes of ischemic stroke and provides guidance for clinical treatment and improvement of the prognosis of ischemic stroke.
[Keywords] middle cerebral artery stenosis or occlusion；ischemic stroke；magnetic resonance imaging；quantitative susceptibility mapping；iron deposition

MAO Huimin1, 2   WANG Xinyi1*   CHEN Kunjian1, 2   GUO Yu1, 2   WANG Xinyu1, 2  

1 Department of Radiology, the First Affiliated Hospital of Shandong First Medical University (Shandong Province Qianfoshan Hospital), Jinan 250014, China

2 Shandong First Medical University, Tai'an 271000, China

Wang XY, E-mail: wxy_88@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Shandong Science and Technology Development Plan Project (No. 2009GG10002024).
Received  2021-07-01
Accepted  2021-08-04
DOI: 10.12015/issn.1674-8034.2021.11.004
Cite this article as: Mao HM, Wang XY, Chen KJ, et al. Preliminary study of quantitative susceptibility mapping in the brain iron deposition of unilateral middle cerebral artery stenosis or occlusion[J]. Chin J Magn Reson Imaging, 2021, 12(11): 16-20. DOI:10.12015/issn.1674-8034.2021.11.004.

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