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• Original Article •
Cerebellar-cortical functional connectivity abnormalities in individuals with nicotine dependence
ZHANG Mengzhe  GAO Xinyu  YANG Zhengui  HUANG Huiyu  WEN Mengmeng  WANG Weijian  CHENG Jingliang  ZHANG Yong  XU Ke 

Cite this article as: Zhang MZ, Gao XY, Yang ZG, et al. Cerebellar-cortical functional connectivity abnormalities in individuals with nicotine dependence[J]. Chin J Magn Reson Imaging, 2021, 12(11): 42-45. DOI:10.12015/issn.1674-8034.2021.11.009.


[Abstract] Objective To explore the neuromechanism of nicotine dependence (ND), this study used resting-state functional magnetic resonance imaging (rs-fMRI) to analyze cerebellar-cortical functional connectivity (FC) abnormalities in long-term smokers.Materials and Methods: One hundred and seventeen long-term smokers and 52 non-smoking volunteers matched with age and education were recruited through the network platform. Using rs-fMRI data, we chose bilateral CrusⅠ as the region of interest (ROI), and calculated the FC between bilateral CrusⅠ and other brain regions to compare the differences of cerebellar-cortical FC between smokers and healthy controls (HCs).Results Compared with HCs, we found increased FC between the left CrusⅠ and brain regions involved in the default mode network (DMN), sensory and motor system in smokers (t=3.56, clusters≥20). The FC between right CrusⅠand cortex in smokers were not significantly different from those in HCs.Conclusions Long-term smokers showed multiple abnormalities in cerebellar-cortical functional connectivity, and these may be the underlying neuromechanism of nicotine dependence, which are associated with automatized smoking behavior, cognitive and attention deficits.
[Keywords] nicotine；functional connectivity；cerebellum；default mode network；magnetic resonance imaging

ZHANG Mengzhe   GAO Xinyu   YANG Zhengui   HUANG Huiyu   WEN Mengmeng   WANG Weijian   CHENG Jingliang   ZHANG Yong*   XU Ke  

Department of Magnetic Resonance, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Zhang Y, E-mail: zzuzhangyong2013@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Joint Construction Project of Henan Medical Science and Technology (No. LHGJ20200381).
Received  2021-05-07
Accepted  2021-08-06
DOI: 10.12015/issn.1674-8034.2021.11.009
Cite this article as: Zhang MZ, Gao XY, Yang ZG, et al. Cerebellar-cortical functional connectivity abnormalities in individuals with nicotine dependence[J]. Chin J Magn Reson Imaging, 2021, 12(11): 42-45. DOI:10.12015/issn.1674-8034.2021.11.009.

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