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Application value of functional magnetic resonance in early diagnosing autoimmune encephalitis in and evaluating the prognosis in children
ZHANG Xiaomeng  SU Qin  LI Linlin  ZHUANG Mengli  CHAOLUMEN Qiqige 

Cite this article as: Zhang XM, Su Q, Li LL, et al. Application value of functional magnetic resonance in early diagnosing autoimmune encephalitis in and evaluating the prognosis in children[J]. Chin J Magn Reson Imaging, 2021, 12(11): 57-60, 65. DOI:10.12015/issn.1674-8034.2021.11.012.


[Abstract] Objective To explore the early diagnostic and prognostic value of functional magnetic resonance imaging (fMRI) in children with autoimmune encephalitis (AE).Materials and Methods: From January 2018 to May 2019, 50 children with AE and 80 children with viral encephalitis (VE) who were admitted to the Affiliated Hospital of Inner Mongolia Medical University Hospital were selected as the AE group and the VE group, respectively. MRI scans, diffusion weighted imaging (DWI), arterial spin label (ASL) perfusion imaging and 1H-magnetic resonance spectroscopy (1H-MRS) were performed respectively. The relative apparent diffusion coefficient (rADC) values of the lesion area, the normal area and the two relative ADC values were measured using DWI images, relative cerebral blood flow (rCBF) using ASL, and choline (Cho) near 2.01 ppm, N-Acetyl-L-aspartic acid (NAA) near 2.01 ppm, creatine (Cr) near 3.03 ppm and other markers and the areas under the peaks of CHo/NAA, Cho/Cr, and NAA/Cr using 1H-MRS image; the relative ratio of the area of the markers was calculated. The children with VE were grouped according to the different prognosis, and the SPSS 22.0 statistical software package was used for data analysis. ROC curve was established to analyze the diagnostic value of each functional parameter for VE and the predictive value of the prognosis of the children.Results The values of rADC and NAA/Cr in the AE group were higher than those in the VE group, and the values of relative regional cerebral blood flow (rrCBF) and Cho/Cr were lower than those in the VE group (t=17.979, 7.250, 4.982, 5.174, P＜0.05). There was no significant difference in Cho/NAA between the two groups (P＞0.05). The values of rADC and rCBFof children with poor prognosis VE were higher than those with good prognosis, and values of NAA/Cr were lower than those with good prognosis (t=2.835, 2.282, 2.162, P＜0.05).Conclusions The rADC value in DWI, the rrCBF value in ASL, and the NAA/Cr value in 1H-MRS have a certain application value in the early differential diagnosis of AE and VE, and may reflect the prognosis of children with AE to a certain extent.
[Keywords] functional magnetic resonance imaging；autoimmune encephalitis；viral encephalitis；prognosis；diagnostic value

ZHANG Xiaomeng   SU Qin   LI Linlin   ZHUANG Mengli   CHAOLUMEN Qiqige*  

Department of Pediatrics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China

Chaolumen QQG, E-mail: chaolumenqi@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS "Science and Technology Millions Project" Project of Inner Mongolia Medical University (No. YKD2018KJBW-LH-019).
Received  2021-02-03
Accepted  2021-08-05
DOI: 10.12015/issn.1674-8034.2021.11.012
Cite this article as: Zhang XM, Su Q, Li LL, et al. Application value of functional magnetic resonance in early diagnosing autoimmune encephalitis in and evaluating the prognosis in children[J]. Chin J Magn Reson Imaging, 2021, 12(11): 57-60, 65. DOI:10.12015/issn.1674-8034.2021.11.012.

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