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• Clinical Article •
A preliminary study on the efficacy of tumor necrosis factor alpha antagonists in the treatment of axial spondyloarthropathy by T1-mapping technique
YU Shun  SU Jiawei  LIN Mingui  CHEN Xianyuan  MA Mingping 

Cite this article as: Yu S, Su JW, Lin MG, et al. A preliminary study on the efficacy of tumor necrosis factor alpha antagonists in the treatment of axial spondyloarthropathy by T1-mapping technique[J]. Chin J Magn Reson Imaging, 2022, 13(1): 21-25, 36. DOI:10.12015/issn.1674-8034.2022.01.005.


[Abstract] Objective To explore the use of MRI T1-mapping technique to evaluate the efficacy of tumor necrosis factor-α antagonists in the treatment of axial spondyloarthropathy (axSpA), in order to provide effective quantitative indicators for the evaluation of axSpA treatment.Materials and Methods One hundred and fourteen study subjects were included, of which 15 normal sacroiliac joint subjects excluded from the diagnosis of axSpA were the control group, and 99 clinically confirmed axSpA patients were the case group, twenty patients in the case group were treated with systemic TNF-α antagonists as the treatment group. The case group was divided into active group and inactive group. The active group was divided into three subgroups: moderate activity group, high activity group and very high activity group. The treatment group was divided into pre-treatment group and 3 weeks treatment group, 6 weeks treatment group and 12 weeks treatment group according to the different time of treatment. All subjects underwent T1-mapping sequence examination to compare the differences in T1-mapping values of the sacroiliac joint subchondral bone marrow area between the control group, the case group, and the subgroups of the case group, using ROC curve to analyze the diagnostic efficacy and monitoring of therapeutic efficacy of different treatment cycles in the treatment group.Results (1) There was no significant difference in the T1-mapping value of the subchondral bone marrow area of the sacroiliac joint and iliac joint in each group, all P＞0.05; (2) Compared with the control group, the T1-mapping value of the bone marrow area under the sacroiliac articular cartilage of the case group increased to varying degrees, T1-mapping value had a good diagnostic efficiency for the high activity group and the very high activity group; (3) The decrease rate of T1-mapping value in the subchondral bone marrow area of sacroiliac joint in different treatment cycles in the treatment group could effectively monitor the curative effect.Conclusions T1-mapping technology can quantitatively evaluate axSpA inflammatory activity, and effectively monitor the efficacy, which is beneficial to clinical individualized treatment and timely adjustment of treatment plans.
[Keywords] axial spondyloarthropathy；ankylosing spondylitis；tumor necrosis factor-α；T1-mapping；bone marrow edema

YU Shun*   SU Jiawei   LIN Mingui   CHEN Xianyuan   MA Mingping  

Shengli Clinical Medical College of Fujian Medical University, Department of Radiology of Fujian Provincial Hospital, Fuzhou 350001, China

Yu S, E-mail: 76429310@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Fujian Provincet (No. 2017J01172); Sky imaging research fund development project of China International Medical Exchange Foundation (No. Z-2014-07-1912-14); Young and Middle-aged Key Personnel Training Project of Fujian Provincial Health Commission (No. 2020GGA005).
Received  2021-06-21
Accepted  2021-11-10
DOI: 10.12015/issn.1674-8034.2022.01.005
Cite this article as: Yu S, Su JW, Lin MG, et al. A preliminary study on the efficacy of tumor necrosis factor alpha antagonists in the treatment of axial spondyloarthropathy by T1-mapping technique[J]. Chin J Magn Reson Imaging, 2022, 13(1): 21-25, 36. DOI:10.12015/issn.1674-8034.2022.01.005.

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