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Research progress of proton magnetic resonance spectroscopy in primary insomnia
ZHAO Shuyi  SU Zengfeng 

Cite this article as: Zhao SF, Su ZF. Research progress of proton magnetic resonance spectroscopy in primary insomnia[J]. Chin J Magn Reson Imaging, 2022, 13(1): 157-160. DOI:10.12015/issn.1674-8034.2022.01.037.


[Abstract] Primary insomnia (PI) is one of the most common sleep disorders. Although we have made some progress in the study of the nature, etiology and pathophysiology of insomnia, there is still no universally accepted pathophysiological model. Today, the most widely accepted hypothesis is that PI is a manifestation of an over-arousal state.Proton magnetic resonance spectroscopy (1H-MRS) provides a non-invasive method to measure the levels of various neurotransmitter and metabolites in the brain, emerging the multi-voxel magnetic resonance spectroscopy can even measure the concentration of neurotransmitters and metabolites in specific brain areas, for the primary insomnia of pathophysiology, pathogenesis, diagnosis and treatment of research provides a fresh view. This paper systematically summarized the domestic and foreign research results and development process of different neurotransmitters and metabolites in various brain regions of primary insomnia by means of magnetic resonance spectroscopy, providing a new perspective for further exploration of the pathophysiological mechanism, diagnosis and treatment of primary insomnia.
[Keywords] primary insomnia；proton magnetic resonance spectroscopy；neurotransmitter；review literature

ZHAO Shuyi   SU Zengfeng*  

Department of General Practice, Chaohu Hospital of Anhui Medical University, Chaohu 238000, China

Su ZF, E-mail: suzengfeng@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Scientific Research Fund Project of Anhui Medical University (No. 2020xkj219, 2021zhyx-C56).
Received  2021-08-23
Accepted  2021-11-10
DOI: 10.12015/issn.1674-8034.2022.01.037
Cite this article as: Zhao SF, Su ZF. Research progress of proton magnetic resonance spectroscopy in primary insomnia[J]. Chin J Magn Reson Imaging, 2022, 13(1): 157-160. DOI:10.12015/issn.1674-8034.2022.01.037.

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