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• Clinical Article •
The study of ischemic core volume combined with the relative perfusion ratio in evaluating vascular recanalization and prognosis in acute stroke
LI Dong  PENG Mingyang  WANG Tongxing  CHEN Guozhong  Yin Xindao  WU Gang 

Cite this article as: Li D, Peng MY, Wang TX, et al. The study of ischemic core volume combined with the relative perfusion ratio in evaluating vascular recanalization and prognosis in acute stroke[J]. Chin J Magn Reson Imaging, 2022, 13(2): 1-5. DOI:10.12015/issn.1674-8034.2022.02.001.


[Abstract] Objective To investigate the value of ischemic core volume (ICV) combined with the relative perfusion ratio before endovascular thrombectomy (EVT) in evaluating vascular recanalization and outcome in acute stroke.Materials and Methods A total of 200 acute ischemic stroke patients in our hospital were analyzed retrospectively. All patients underwent MRI examination before therapy within 24 h. Perfusion weighting ICV (pw-ICV) was defined as ICV multiply by relative cerebral blood flow (rCBF). Complete recanalization was assessed by mTICI grading (0-2a: incomplete recanalization; 2b-3: complete recanalization); the outcome was evaluated by using mRS score at 3 months (0-2 score: good outcome; 3-6 score: poor outcome). Statistical analysis was performed to evaluate the value of pw-ICV in predicting vascular recanalization and outcome.Results Compared with incomplete revascularization group (n=68), the complete revascularization group had a smaller ICV before therapy was (27.31±19.18 vs. 54.45±29.87) and smaller pw-ICV (103.82±77.46 vs. 216.20±88.19), the difference was statistically significant (P＜0.05). Compared with the outcome group (n=129), the good outcome group (n=71) had a lower NIHSS score (15.71±6.18 vs. 18.27±6.37), smaller ICV before therapy (28.42±17.38 vs. 53.51±28.79) and smaller pw-ICV (113.27±79.61 vs. 221.07±87.37) and higher recanalization rate (89.15% vs. 23.94%), the difference was statistically significant (P＜0.05). Logistic multiple logistic regression analysis showed that pw-ICV (OR 0.930; 95% CI: 0.854-1.465; P=0.016) was an independent predictor of recanalization in acute stroke; pw-ICV (OR 0.971; 95% CI: 0.551-1.865; P=0.025) and complete recanalization (OR 5.26; 95% CI: 1.572-13.179; P=0.037) were independent predictor of the outcome in acute stroke.Conclusions pw-ICV plays an important role in recanalization and outcome of acute ischemic stroke before EVT therapy.
[Keywords] stroke；magnetic resonance imaging；perfusion imaging；ischemic core volume；vascular recanalization；prognosis

LI Dong1   PENG Mingyang2   WANG Tongxing2   CHEN Guozhong2   Yin Xindao2   WU Gang2*  

1 Department of Medical Imaging, Jiangyin Hospital of Traditional Chinese Medicine, Wuxi 214400, China

2 Department of Medical Imaging, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

Wu G, E-mail: doc__wu@139.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82001811); Natural Science Foundation of Jiangsu Province (No. BK20201118).
Received  2021-07-02
Accepted  2021-12-28
DOI: 10.12015/issn.1674-8034.2022.02.001
Cite this article as: Li D, Peng MY, Wang TX, et al. The study of ischemic core volume combined with the relative perfusion ratio in evaluating vascular recanalization and prognosis in acute stroke[J]. Chin J Magn Reson Imaging, 2022, 13(2): 1-5. DOI:10.12015/issn.1674-8034.2022.02.001.

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